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Full-Text Articles in Biomedical Engineering and Bioengineering
A Protocol For Coupling Volumetrically Dynamic In Vitro Experiments To Numerical Physiology Simulation For A Hybrid Cardiovascular Model, Abraham Umo, Ethan Kung
A Protocol For Coupling Volumetrically Dynamic In Vitro Experiments To Numerical Physiology Simulation For A Hybrid Cardiovascular Model, Abraham Umo, Ethan Kung
Publications
Objective: The Physiology Simulation Coupled Experiment (PSCOPE) is a hybrid modeling framework that enables a physical fluid experiment to operate in the context of a closed-loop computational simulation of cardiovascular physiology. Previous PSCOPE methods coupled rigid experiments to a lumped parameter network (LPN) of physiology but are incompatible with volumetrically dynamic experiments where fluid volume varies periodically. We address this limitation by introducing a method capable of coupling rigid, multi-branch, and volumetrically dynamic in-vitro experiments to an LPN. Methods: Our proposed method utilizes an iterative weighted-averaging algorithm to identify the unique solution waveforms for a given PSCOPE model. We confirm …
Tunable Blood Shunt For Neonates With Complex Congenital Heart Defects, Ellen Garver, Christopher B. Rodell, Kristen Shema, Krianthan Govender, Samantha E. Cassel, Bryan Ferrick, Gabriella Kupsho, Ethan Kung, Kara L. Spiller, Randy Stevens, Amy L. Throckmorton
Tunable Blood Shunt For Neonates With Complex Congenital Heart Defects, Ellen Garver, Christopher B. Rodell, Kristen Shema, Krianthan Govender, Samantha E. Cassel, Bryan Ferrick, Gabriella Kupsho, Ethan Kung, Kara L. Spiller, Randy Stevens, Amy L. Throckmorton
Publications
Despite advancements in procedures and patient care, mortality rates for neonatal recipients of the Norwood procedure, a palliation for single ventricle congenital malformations, remain high due to the use of a fixed-diameter blood shunt. In this study, a new geometrically tunable blood shunt was investigated to address limitations of the current treatment paradigm (e.g., Modified Blalock-Taussig Shunt) by allowing for controlled modulation of blood flow through the shunt to accommodate physiological changes due to the patient’s growth. First, mathematical and computational cardiovascular models were established to investigate the hemodynamic requirements of growing neonatal patients with shunts and to inform design …
Pediatric Cardiac Devices: Recent Progress And Remaining Problems, Kyle Crawford, Martine Leberge, Dan Simionescu, Naren Vyavahare
Pediatric Cardiac Devices: Recent Progress And Remaining Problems, Kyle Crawford, Martine Leberge, Dan Simionescu, Naren Vyavahare
Publications
Pediatric cardiology is a field that largely relies on translation of innovation in its adult counterpart in order to improve patient outcomes and introduce new technology to the field. Few FDA-approved pediatric cardiac devices are available for clinical use, thus leading to widespread off-label use within the field. Nonetheless, adaption of devices and technology from the adult field has proven to improve patient outcomes and overall wellness. However, the diversity of congenital heart disease, in terms of basic anatomy and treatment response, continues to complicate results. The combination of diversity of anatomy and small population size make it difficult for …