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Full-Text Articles in Biomedical Engineering and Bioengineering
The Synthesis And Characterization Of Dual-Modified Carboxymethylcellulose For Bioadhesive Applications, Fabrice Bernard
The Synthesis And Characterization Of Dual-Modified Carboxymethylcellulose For Bioadhesive Applications, Fabrice Bernard
Dissertations and Theses
Reparative medical techniques, in conjunction with existing and emerging tissue adherents and sealants, offer practicing physicians a wide variety of tools to improve the functionality, performance, and safety of surgical interventions. Carboxymethylcellulose (CMC) is a plant-derived polymer that is cytocompatible, biocompatible, biodegradable, and inexpensive. The need for a non-toxic but strongly adherent material motivated the development of an injectable bioadhesive system containing CMC modified with functional methacrylate and aldehyde groups that could potentially be used as an annulus fibrosus sealant or as a supplement to existing wound closure materials. After modification, the polymer was characterized via NMR spectroscopy, Schiff’s base …
Assessment Of Injection Behavior Of Commercially-Available Bone Bsms For Subchondroplasty Procedures, Dinely A. Colon
Assessment Of Injection Behavior Of Commercially-Available Bone Bsms For Subchondroplasty Procedures, Dinely A. Colon
Dissertations and Theses
Subchondroplasty is a procedure that utilized bone substitutes materials (BSMs) or bone cement to correct bone defects in the subchondral bone. The two main materials used to compose BSMs are poly-methyl-methacrylate (PMMA) and calcium phosphate cement (CaP). Currently, there is no optimal bone material substitute in the market that can provide both the adequate mechanical support and the right viscosity to reach the affected area in the subchondral bone. In addition, there is also no established parameter for their proper use, based on the defect size and location. PMMA possesses comparable mechanical properties to bone (i.e. 96 MPa in compressive …
Morphology Of Brain Sulci Trabeculae And Its Effect On Brain During Impacts, Sharlin Anwar
Morphology Of Brain Sulci Trabeculae And Its Effect On Brain During Impacts, Sharlin Anwar
Dissertations and Theses
Traumatic brain injury (TBI) is an intracranial injury caused by direct contact or non-contact head impacts to the brain. TBI is a major problem that accounts for high incidents of hospitalizations each year. Thus, it is important to understand and predict the occurrence of TBI in an impact. It has been shown that the subarachnoid space (SAS) trabeculae play an important role in damping the effect of an impact, thus reducing the injuries. However, the influence of sulci parameters and the sulci trabeculae in TBI due to impact is unexplored. Studies have shown that inclusion of sulci in brain models …
Calibration And Validation Of An In Vitro Ultrasound Device To Deliver Targeted Thermal Enhancement Of Hmsc Osteogenesis, Dionne Dawkins
Calibration And Validation Of An In Vitro Ultrasound Device To Deliver Targeted Thermal Enhancement Of Hmsc Osteogenesis, Dionne Dawkins
Dissertations and Theses
Osteoarthritis (OA) is a disease that affects millions of people annually, often the elderly, and limits their physical abilities. Current methods of treating OA are often very invasive, and expensive, costing the Medicare system billions of dollars annually. A minimally invasive therapy that can be localized to the affected area that provides both relief and a short recovery time is optimal for treating the disease. For targeted therapy and clinical use, therapeutic ultrasound in the 0.7 MHz to 3 MHz frequency range can provide relief and is convenient, portable and localized. Low-intensity pulsed ultrasound (LIPUS) has been proven in clinical …
Chemotaxis Of Central Nervous System-Derived Tumor Cells Within Controlled Microenvironments, Jennifer Rico Varela
Chemotaxis Of Central Nervous System-Derived Tumor Cells Within Controlled Microenvironments, Jennifer Rico Varela
Dissertations and Theses
Medulloblastoma (MB) is a malignant pediatric brain tumor known for its aggressive metastatic potential. Despite the well-documented migration of MB cells to other parts of the brain and spinal column, MB chemotaxis is poorly understood. Herein, we examined the in vitro migratory and cellular responses of MB-derived cells to external signaling of Epidermal Growth Factor (EGF), hepatocyte growth factor (HGF), platelet-derived growth factor (PDGF-BB), and the stromal cell-derived factors 1-alpha (SDF-1). Experiments utilized transwell assays and immunocytochemistry to identify receptor activation in MB migration, and used a microfluidic platform to examine directionality, trajectory, and gradient- dependence of motile cells. Data …