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Full-Text Articles in Biomedical Engineering and Bioengineering
Vascular Reactivity In Newly-Formed And Mature Arterialized Collateral Capillaries, Sara K. Hellstrom
Vascular Reactivity In Newly-Formed And Mature Arterialized Collateral Capillaries, Sara K. Hellstrom
Master's Theses
Peripheral arterial occlusive disease (PAOD) is a globally-prevalent cardiovascular disease in which atherosclerotic plaques narrow arterial lumen diameters and restrict blood flow to downstream tissues. The impact of these occlusions can be mitigated by collateral vessels that connect parallel arterial branches and act as natural bypasses to maintain perfusion. In animal models that lack collateral arterioles, capillaries that connect terminal arteriolar segments can arterialize and form functional collaterals following an ischemic event; however, in the early stages of development, vasodilation is impaired. We explored the mechanism of impaired vasodilation in arterialized collateral capillaries (ACCs) and pre-existing collaterals (PECs) by evaluating …
Investigating Hemodynamic Responses To Electrical Neurostimulation, Sean Youra
Investigating Hemodynamic Responses To Electrical Neurostimulation, Sean Youra
Master's Theses
Since the 1900s, the number of deaths attributable to cardiovascular disease has steadily risen. With the advent of antihypertensive drugs and non-invasive surgical procedures, such as intravascular stenting, these numbers have begun to level off. Despite this trend, the number of patients diagnosed with some form of cardiovascular disease has only increased. By 2030, prevalence of coronary heart disease is expected to increase approximately by 18% in the United States. By 2050, prevalence of peripheral arterial occlusive disease is expected to increase approximately by 98% in the U.S. No single drug or surgical intervention offers a complete solution to these …