Biomedical Engineering and Bioengineering Commons^™

A Computational Framework To Model Mesenchymal Stem Cell Nucleus Mechanics Using Confocal Microscopy, Zeke Kennedy

Boise State University Theses and Dissertations

The mechanical properties of the cell nucleus are emerging as a key component in genetic transcription. It has been shown that the stiffness of the nucleus in part regulates the transcription of genes in response to external mechanical stimuli. The stiffness has been shown to change as a result of both disease and changes to the external environment. While the mechanical structure of the nucleus can be visually documented using a confocal microscope, it is currently impossible to test the stiffness of the nucleus without a mechanical testing apparatus such as an atomic force microscope. This is problematic in that …