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Full-Text Articles in Biomedical Engineering and Bioengineering
Novel On-Demand Droplet Generation For Selective Fluid Sample Extraction, Melinda Simon, Jeffrey Fisher, Melinda Simon, Abraham Lee
Novel On-Demand Droplet Generation For Selective Fluid Sample Extraction, Melinda Simon, Jeffrey Fisher, Melinda Simon, Abraham Lee
Faculty Publications
A novel microfluidic device enabling selective generation of droplets and encapsulation of targets is presented. Unlike conventional methods, the presented mechanism generates droplets with unique selectivity by utilizing a K-junction design. The K-junction is a modified version of the classic T-junction with an added leg that serves as the exit channel for waste. The dispersed phase fluid enters from one diagonal of the K and exits the other diagonal while the continuous phase travels in the straight leg of the K. The intersection forms an interface that allows the dispersed phase to be controllably injected through actuation of an elastomer …
Characterization Of Elastic-Like Polypeptide Micelles Using Capillary Viscometry, Sumit H. Kambow
Characterization Of Elastic-Like Polypeptide Micelles Using Capillary Viscometry, Sumit H. Kambow
ETD Archive
Elastin-like polypeptides (ELPs) are a part of the family of responsive polymers. These polymers can be made to respond to a wide variety of stimuli, including temperature, pH, salt, concentration, light, and solvent. Elastin-like polypeptides are soluble in water at low temperatures but they become hydrophobic and insoluble above their transition temperature. Elastin-like polypeptides, (GVGVP)40-foldon and (GVGVP)60-foldon, were expressed in bacterial system. These ELPs above their transition temperature, Tt, at low salt (< 45mM) and high pH (> pH 10) assemble into micelles where the hydrophobic tails phase separate in the interior of the micelle as an immiscible coacervate phase. The oligomerization domain termed as …