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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 3 of 3
Full-Text Articles in Biomedical Engineering and Bioengineering
Differential Mitochondrial Toxicity Screening And Multi- Parametric Data Analysis, Maria V. Tsiper, Jennifer Sturgis, Larisa V. Avramova, Shilpa Parakh, Raymond Fatig, Ana Juan-García, Nianyu Li, Bartek Rajwa, Padma Narayanan, C. W. Wualls Jr., Joseph P. Robinson, Vincent J. Davisson
Differential Mitochondrial Toxicity Screening And Multi- Parametric Data Analysis, Maria V. Tsiper, Jennifer Sturgis, Larisa V. Avramova, Shilpa Parakh, Raymond Fatig, Ana Juan-García, Nianyu Li, Bartek Rajwa, Padma Narayanan, C. W. Wualls Jr., Joseph P. Robinson, Vincent J. Davisson
Weldon School of Biomedical Engineering Faculty Publications
Early evaluation of new drug entities for their potential to cause mitochondrial dysfunction is becoming an important task for drug development. Multi-parametric high-content screening (mp-HCS) of mitochondrial toxicity holds promise as a lead in-vitro strategy for drug testing and safety evaluations. In this study, we have developed a mp-HCS and multi-parametric data analysis scheme for assessing cell responses to induced mitochondrial perturbation. The mp-HCS measurements are shown to be robust enough to allow for quantitative comparison of biological systems with different metabolic pathways simulated by alteration of growth media. Substitution of medium glucose for galactose sensitized cells to drug action …
Predicting Success Or Failure Of Immunotherapy For Cancer: Insights From A Clinically Applicable Mathematical Model, Charles F. Babbs
Predicting Success Or Failure Of Immunotherapy For Cancer: Insights From A Clinically Applicable Mathematical Model, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Publications
The objective of this study was to create a clinically applicable mathematical model of immunotherapy for cancer and use it to explore differences between successful and unsuccessful treatment scenarios. The simplified predator-prey model includes four lumped parameters: tumor growth rate, g; immune cell killing efficiency, k; immune cell signaling factor, λ; and immune cell half-life decay, μ. The predator-prey equations as functions of time, t, for normalized tumor cell numbers, y, (the prey) and immunocyte numbers, x, (the predators) are: dy/dt = gy – kx and dx/dt = λxy – μx. A parameter estimation procedure that capitalizes on available clinical …
Optimizing Electrode Placement For Hemodynamic Benefit In Cardiac Resynchronization Therapy, Charles F. Babbs
Optimizing Electrode Placement For Hemodynamic Benefit In Cardiac Resynchronization Therapy, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Publications
Background: Research is needed to explore the relative benefits of alternative electrode placements in biventricular and left ventricular pacing for heart failure with left bundle branch block (LBBB). Methods: A fast computational model of the left ventricle, running on an ordinary laptop computer, was created to simulate the spread of electrical activation over the myocardial surface, together with the resulting electrocardiogram, segmental wall motion, stroke volume, and ejection fraction in the presence of varying degrees of mitral regurgitation. Arbitrary zones of scar and blocked electrical conduction could be modeled. Results: Simulations showed there are both sweet spots and poor spots …