Biomedical Engineering and Bioengineering Commons^™

Modification Of A Novel Polymer With Potential Use In Artificial Heart Valves : Effects On Hemocompatibility And Mechanical Properties, Tejas Dilipkumar Choksi

FIU Electronic Theses and Dissertations

Platelet mediated thrombosis has been a major source of mortality and morbidity in cardiovascular device patients as the device surface upon contact with blood induces surface thrombosis. Two specific objectives of this thesis are: 1) Identify the effect of phospholipid modification on Quatromer and 2) Identify the most effective modification technique that will inhibit the surface induced thrombosis and enhance the long-term blood compatibility of Quatromer. Six different phospholipids were grafted in the Quatromer and the role of each of the modified substrates was evaluated in terms of mechanical properties and hemocompatibility. The surface analysis studies showed a significant decrease …