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Full-Text Articles in Biomedical Engineering and Bioengineering
Design, Development And Biomechanical Analysis Of Scaffolds For Augmentation Of Rotator Cuff Repairs, Amit Aurora
Design, Development And Biomechanical Analysis Of Scaffolds For Augmentation Of Rotator Cuff Repairs, Amit Aurora
ETD Archive
Rotator cuff tears are a source of debilitating pain that commonly affects more than 40 of our aging population. Despite advances in surgical treatment, the failure rate of rotator cuff repairs is as high as 20-90 . Extracellular matrix (ECM) derived scaffolds have recently been investigated as augmentation devices for rotator cuff repairs, but none has yet demonstrated both the appropriate biological and mechanical properties for mitigating re-tears and enhancing healing. This dissertation proposes to engineer the mechanical properties of allograft fascia lata in a manner that will allow its use as an augmentation device for rotator cuff repairs. This …
Surface Microtopography Modulation Of Biomaterials For Bone Tissue Engineering Applications, Eun Jung Kim
Surface Microtopography Modulation Of Biomaterials For Bone Tissue Engineering Applications, Eun Jung Kim
ETD Archive
The ultimate goal of this project is to develop a biodegradable and implantable scaffold with precise surface topographies that can provide osteoconductive stimuli to connective tissue progenitor cells (CTPs), and subsequently, enhance bone regeneration applications without the complications of autogenous cancellous bone grafts. This dissertation presents the modification of surface microtextures to provide osteoconductive stimuli to CTPs for bone regeneration applications. First, the effect of surface topography on cell proliferation and osteogenic differentiation was validated through experiments using surface post microtextures and CTPs. Post microtextures accelerated CTP growth behaviors compared to smooth polydimethylsiloxane (PDMS) and standard cell culture dishes. Second, …