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Full-Text Articles in Biomedical Engineering and Bioengineering
Short-Pulse Laser Propagation Through Tissue Medium For Tumor Detection, Gopalendu Pal, Kunal Mitra, Tuan Vo-Dinh
Short-Pulse Laser Propagation Through Tissue Medium For Tumor Detection, Gopalendu Pal, Kunal Mitra, Tuan Vo-Dinh
Biomedical Engineering and Sciences Faculty Publications
The objective of this paper is to perform a comprehensive experimental and numerical analysis of the short pulse laser interaction with tissue medium with the goal of tumor / cancer diagnostics. For short pulse laser source, the shape of output signal is a function of the optical properties of the medium and hence the scattered temporal optical signal helps in understanding of the medium characteristics. Initially experiments are performed on tissue phantoms imbedded with inhomogeneities in order to optimize the time-resolved optical detection scheme. Both the temporal and the spatial profiles of the scattered reflected and transmitted optical signals are …
Short Pulse Laser Propagation Through Tissues, Champak Das, Ashish Trivedi, Kunal Mitra, Tuan Vo-Dinh
Short Pulse Laser Propagation Through Tissues, Champak Das, Ashish Trivedi, Kunal Mitra, Tuan Vo-Dinh
Biomedical Engineering and Sciences Faculty Publications
An experimental and numerical study is performed to analyze short pulse laser propagation through tissue phantoms without and with inhomogeneities/tumors imbedded in it. Short pulse laser probing techniques has distinct advantages over conventional very large pulse width or cw lasers primarily due to the additional information conveyed about the tissue interior by the temporal variation of the observed signal. Both the scattered temporal transmitted and reflected optical signals are measured experimentally using a streak camera for samples irradiated with a short pulse laser source. Parametric study involving different scattering and absorption coefficients of tissue phantoms and inhomogeneities as well as …
Novel Modeling Techniques For Tumor Diagnostics Using Pulsed Laser Sources, Mohamed Sakami, Kunal Mitra, Tuan Vo-Dinh
Novel Modeling Techniques For Tumor Diagnostics Using Pulsed Laser Sources, Mohamed Sakami, Kunal Mitra, Tuan Vo-Dinh
Biomedical Engineering and Sciences Faculty Publications
In this paper, a two-dimensional transient radiation transport algorithm is developed to analyze short pulse laser transport through a tissue medium having tumors and inhomogeneities imbedded in it. Short pulse probing techniques have distinct advantages over conventional very large pulse width or cw lasers primarily due to the additional information conveyed about the tissue interior by the temporal variation of the observed signal. The distinct feature is the multiple scattering induced temporal signatures that persists for time periods greater than the duration of the source pulse and is a function of the source pulse width, the scattering/absorbing properties and nature …
Use Of Short-Pulse Laser For Optical Tomography Of Tissues, Kunal Mitra, Tuan Vo-Dinh
Use Of Short-Pulse Laser For Optical Tomography Of Tissues, Kunal Mitra, Tuan Vo-Dinh
Biomedical Engineering and Sciences Faculty Publications
This paper analyzes the short pulse laser propagation through tissues for development of a time-resolved optical tomography system for detection of tumors and inhomogeneities in tissues. Traditional method for analyzing optical transport in tissues is the parabolic or diffusion approximation in which the energy flux is assumed proportional to the fluence (intensity averaged over all solid angles) gradients. The inherent drawback in this model is that it predicts infinite speed of propagation of the optical signal. In this paper accurate hyperbolic or wave nature of transient radiative transfer formulation is used to overcome such drawbacks. The transmitted and reflected intensity …