Biomedical Engineering and Bioengineering Commons^™

Reference Point Indentation Is Not Indicative Of Whole Mouse Bone Measures Of Stress Intensity Fracture Toughness, Alessandra Carriero, Jan L. Bruse, Karla J. Oldknow, José Luis Millán, Colin Farquharson, Sandra J. Shefelbine

Biomedical Engineering and Sciences Faculty Publications

Bone fragility is a concern for aged and diseased bone. Measuring bone toughness and understanding fracture properties of the bone are critical for predicting fracture risk associated with age and disease and for preclinical testing of therapies. A reference point indentation technique (BioDent) has recently been developed to determine bone's resistance to fracture in a minimally invasive way by measuring the indentation distance increase (IDI) between the first and last indentations over cyclic indentations in the same position. In this study, we investigate the relationship between fracture toughness KC and reference point indentation parameters (i.e. IDI, total indentation distance (TID) …