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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Investigation Of Human Adipose-Derived Stem-Cell Behavior Using A Cell-Instructive Polydopamine-Coated Gelatin-Alginate Hydrogel., Settimio Pacelli, Aparna R Chakravarti, Saman Modaresi, Siddharth Subham, Kyley Burkey, Cecilia Kurlbaum, Madeline Fang, Christopher A Neal, Adam J Mellott, Aishik Chakraborty, Arghya Paul
Investigation Of Human Adipose-Derived Stem-Cell Behavior Using A Cell-Instructive Polydopamine-Coated Gelatin-Alginate Hydrogel., Settimio Pacelli, Aparna R Chakravarti, Saman Modaresi, Siddharth Subham, Kyley Burkey, Cecilia Kurlbaum, Madeline Fang, Christopher A Neal, Adam J Mellott, Aishik Chakraborty, Arghya Paul
Chemical and Biochemical Engineering Publications
Hydrogels can be fabricated and designed to exert direct control over stem cells' adhesion and differentiation. In this study, we have investigated the use of polydopamine (pDA)-treatment as a binding platform for bioactive compounds to create a versatile gelatin-alginate (Gel-Alg) hydrogel for tissue engineering applications. Precisely, pDA was used to modify the surface properties of the hydrogel and better control the adhesion and osteogenic differentiation of human adipose-derived stem cells (hASCs). pDA enabled the adsorption of different types of bioactive molecules, including a model osteoinductive drug (dexamethasone) as well as a model pro-angiogenic peptide (QK). The pDA treatment efficiently retained …
Production Of Lignin-Based Phenolic Resins Using De-Polymerized Kraft Lignin And Process Optimization, Homaira Siddiqui
Production Of Lignin-Based Phenolic Resins Using De-Polymerized Kraft Lignin And Process Optimization, Homaira Siddiqui
Electronic Thesis and Dissertation Repository
Commercialization of Lignin-based phenol formaldehyde resins (LPF) has been limited due to the increase in curing temperatures and decrease in adhesive strength of LPF compared to conventional phenolic resins. Lignin depolymerization can increase the reactivity of lignin; however, the effect of lignin molecular weight on curing performance of LPF resins has yet to be investigated. This research work examined the optimization of synthesis parameters including percent substitution of phenol with lignin, formaldehyde- to-phenol ratio (F/P), and Mw of lignin to reduce the curing temperature and increase the adhesive strength of LPF. DSC analysis indicated that lignin with Mw ~1200g/mol resulted …