Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Bacteria (1)
- Biomaterials (1)
- Biometallic Corrosion (1)
- Bisphosphonate Nanoparticles (1)
- Breast Implants (1)
-
- Dynamic Interfacial Chemical Reactions (1)
- Electrochemistry (1)
- Electromagnetic Radiation (1)
- Extraembryonic lineage cells (1)
- Hemorrhage control (1)
- Heterogeneous Catalysis (1)
- Hydrogel (1)
- Induced pluripotent stem cells (1)
- Inflammation (1)
- Interconnectivity (1)
- Isocyanate (1)
- Macrophages (1)
- Mesenchymal stem cells (1)
- Neural crest stem cells (1)
- Osteoarthritis (1)
- PEG-PLGA (1)
- Phagocytosis (1)
- Polymeric Microparticles (1)
- Polyurethane (1)
- Porous foam (1)
- Shape memory polymer (1)
- Surface Chemistry (1)
- Surface Topography (1)
- Targeted differentiation (1)
- Wound healing (1)
- Publication
Articles 1 - 9 of 9
Full-Text Articles in Biomedical Engineering and Bioengineering
Targeted Mesenchymal Stem Cell Differentiation From Induced Pluripotent Stem Cells For Therapeutic Application, Tackla Winston
Targeted Mesenchymal Stem Cell Differentiation From Induced Pluripotent Stem Cells For Therapeutic Application, Tackla Winston
Dissertations - ALL
Over the past decade, mesenchymal stem cells have increasingly gained interest as a cell source for the treatment of a variety of diseases. This is because they play several roles in tissue homeostasis and regeneration, such as altering the immune response to limit inflammation, aiding tissue repair through the release of various proteins, cytokines and growth factors, or differentiating into functional cells in specific tissues. The interest in MSCs for biomanufacturing applications has resulted in the development of various protocols to differentiate them from pluripotent sources. These protocols, however, fail to account for the differences that exist between MSCs from …
Leveraging Isocyanate Chemistry For Low Cost And Highly Functional Hydrogels, Henry Beaman
Leveraging Isocyanate Chemistry For Low Cost And Highly Functional Hydrogels, Henry Beaman
Dissertations - ALL
The development of novel biomaterials is an important step in providing higher quality products for wound healing, drug delivery, and tissue engineering. Progress is consistently being made in the development of new polymers, yet new polymer systems are often expensive and/or involve complex multistep synthesis methods. These limitations could hinder the translation and scalability of functionalized materials. To address the issues of complex synthesis and high cost, we have devised strategies for polymeric modification using isocyanate chemistry. Isocyanates are used in the manufacturing of polyurethanes. Isocyanates are highly reactive with common functional groups, such as amines, hydroxyls, and carboxylic acids. …
Engineering Temporal And Spatial Complexity In Biomaterial Scaffolds For Cardiac Disease Modeling And Mechanobiology, Chenyan Wang
Engineering Temporal And Spatial Complexity In Biomaterial Scaffolds For Cardiac Disease Modeling And Mechanobiology, Chenyan Wang
Dissertations - ALL
Temporal and spatial mechanical cues play an important role in heart development, function, and disease manifestation. A deeper understanding of cardiac mechanobiology is especially important for fundamental biology and clinical diagnosis or heart disease treatment. Currently, human induced pluripotent stem cells (hiPSCs) are widely used to build human cell or tissue models, but culturing them in a petri dish fail to recapitulate the mechanical complexity in the native heart. To create a mechanical environment with better pathophysiological relevance, biomaterial scaffolds are usually employed to mimic the mechanical cues originated from extracellular matrix (ECM) remodeling. The goal of this dissertation is …
Advanced In Vitro Models For Studying Bone Physiology, Kairui Zhang
Advanced In Vitro Models For Studying Bone Physiology, Kairui Zhang
Dissertations - ALL
Bone is a highly calcified organic-inorganic composite tissue with complicated hierarchical structure. The presence of complex multi-cellular organization within opaque mineralized matrix makes it challenging to use conventional methods to study in vivo bone physiology even using model animals. To address this challenge, numerous in vitro models have been developed to study bone physiology under well-defined and repeatable experimental conditions although proving their physiological relevance remains a key challenge. This work aims to design and develop new in vitro models that better represent in vivo bone physiology with defined control over chemical and physical microenvironments, at low costs and high …
Fabrication Of Polymeric Microparticles Loaded With Zoledronic Acid To Treat Osteoarthritis, Yohely Maria Espiritusanto
Fabrication Of Polymeric Microparticles Loaded With Zoledronic Acid To Treat Osteoarthritis, Yohely Maria Espiritusanto
Theses - ALL
Osteoarthritis (OA), a disease caused by wearing and tearing of articular cartilage, affectsover 32.5 million Americans. Synovial inflammation is now recognized as a major contributor to OA progression and pain. Activated synovial macrophages in an OA joint are believed to play a major role in low grade inflammation found in OA. Bisphosphonates such as zoledronic acid (ZA) are known to induce apoptosis specifically in macrophages and several of them are being evaluated as a disease-modifying osteoarthritis drug in clinical trials. However, ZA is rapidly cleared from the joint after systemic or localized direct injection into the joint. In this study …
Effects Of Surface Topography On Macrophages And Bacterial Cells, Joseph Carnicelli
Effects Of Surface Topography On Macrophages And Bacterial Cells, Joseph Carnicelli
Theses - ALL
An association has been found between the texture of breast implants and anaplastic large cell lymphoma, which led to some textured implants to be withdrawn from the market in 2019. There is evidence that these cancers are associated with the harboring of bacteria on the surfaces of the textured implants. It is possible that specific topographic features hinder the removal of attached bacteria by inhibiting macrophage phagocytosis or promoting biofilm formation. Here we examine how bacteria and macrophages interact with recessive surface topographies as analogs to the surfaces seen on textured breast implants. Changes in bacteria morphology were observed among …
Shape Memory Polymer Foaming With Tunable Interconnectivity Using Off-The-Shelf Foaming Components, Natalie Marie Petryk
Shape Memory Polymer Foaming With Tunable Interconnectivity Using Off-The-Shelf Foaming Components, Natalie Marie Petryk
Theses - ALL
The ability to tune pore structures of gas-blown polyurethane shape memory polymer (SMP) foams easily and safely could improve their outcomes as hemostatic dressings or tissue engineering scaffolds and overall commercialization efforts. Incorporating physical blowing agents into the polymer mix can be used to tune pore size and interconnectivity without altering foam chemistry. Enovate (HFC-254fa) is a commonly used physical blowing agent in gas-blown foams, but the Environmental Protection Agency (EPA) considers its use unacceptable because it is a hydrofluorocarbon that contributes to global warming. Here, off-the-shelf solvents accepted for use by the EPA, acetone, dimethyoxymethane (methylal), and methyl formate, …
Manipulated Electrochemical Surface Reactions Induced By Oscillatory Electric Potentials On Metal Based Electrodes, Thomas Stone Welles
Manipulated Electrochemical Surface Reactions Induced By Oscillatory Electric Potentials On Metal Based Electrodes, Thomas Stone Welles
Dissertations - ALL
This research effort investigates the manipulation of surface electrochemical reactions induced by oscillating electric potentials on the surface of metal-based electrodes. Specifically, this research presents experimental data identifying modified electrochemical surface reactions caused by low magnitude electric potential oscillations on multilayered catalytic membranes and on implanted biometallic alloys. The scope of this effort consists of four major components: (1) perform an exhaustive literature review and analysis of the current understanding in applied surface electrochemistry and develop potential theoretical frameworks by which to interpret the experimental results; (2) identify the electrochemical manipulation via electrical oscillation while reacting nitric oxide on a …
Atomistic Investigation Of Nucleosomal H3 Histone Tail In Unmodified And Epigenetically Modified States, Kathryn Piston
Atomistic Investigation Of Nucleosomal H3 Histone Tail In Unmodified And Epigenetically Modified States, Kathryn Piston
Dissertations - ALL
Epigenetics is a growing area of research that could potentially unlock the understanding of questions like how and why we develop certain diseases, how we age, how we inherit certain traits and even how our species evolves. Epi is a prefix meaning above, referring to chemical tags that sit above your genetics and dictate gene expression. Although there are many known links between certain epigenetic tags and diseases like cancer, the molecular mechanisms behind these links remains elusive. Gaining a novel understanding of the behavior of key biological targets for cancer like the histone H3 tail motivated this work. Histone …