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Full-Text Articles in Biomedical Engineering and Bioengineering
Catechol-Based Antimicrobial Polymers, Seyedehfatemeh Razaviamri, Kan Wang, Bo Liu, Bruce P. Lee
Catechol-Based Antimicrobial Polymers, Seyedehfatemeh Razaviamri, Kan Wang, Bo Liu, Bruce P. Lee
Michigan Tech Publications
Catechol is a key constituent in mussel adhesive proteins and is responsible for strong adhesive property and crosslinking formation. Plant-based polyphenols are also capable of chemical interactions similar to those of catechol and are inherently antimicrobial. This review reports a series of catechol-based antimicrobial polymers classified according to their antimicrobial mechanisms. Catechol is utilized as a surface anchoring group for adhering monomers and polymers of known antimicrobial properties onto various types of surfaces. Additionally, catechol's ability to form strong complexes with metal ions and nanoparticles was utilized to sequester these antimicrobial agents into coatings and polymer matrices. During catechol oxidation, …
Reversibly Switching Adhesion Of Smart Adhesives Inspired By Mussel Adhesive Chemistry, Ameya R. Narkar
Reversibly Switching Adhesion Of Smart Adhesives Inspired By Mussel Adhesive Chemistry, Ameya R. Narkar
Dissertations, Master's Theses and Master's Reports
Catecholic groups in mussel adhesive proteins transition from being strongly adhesive in a reduced state under acidic conditions to being weakly adhesive in an oxidized state under basic conditions. Here, we exploit this pH responsive behavior of catechol and demonstrate that its oxidation state can be manipulated by incorporation of boronic acid to facilitate reversible transitions between strong and weak adhesion. Our first approach involved the addition of 3- acrylamido phenylboronic acid (APBA) to dopamine methacrylamide (DMA) containing adhesives. The synthesized adhesives showed strong adhesion to quartz surface in an acidic medium (pH 3), while weak adhesion was observed on …
Ph Responsive, Adhesive Hydrogels Based On Reversible Catechol - Boronic Acid Complexation, Ameya Ravindra Narkar
Ph Responsive, Adhesive Hydrogels Based On Reversible Catechol - Boronic Acid Complexation, Ameya Ravindra Narkar
Dissertations, Master's Theses and Master's Reports - Open
Smart hydrogel adhesives with tunable properties consist of adhesive moieties in the polymer network that respond to external stimuli like pH, temperature, etc. Responsiveness of smart adhesives to pH, in particular, is important because of the simple actuation mechanism and the ability to achieve facile bonding and debonding upon command. Covalently crosslinked hydrogel adhesives were prepared by employing an N-HEAA (hydroxyethyl acrylamide) backbone embedded with dopamine methacrylamide (DMA), a marine mussel inspired adhesive protein and 3-acrylamido phenylboronic acid (AAPBA), to determine the effect of pH on the interfacial binding properties of the hydrogel adhesive with a borosilicate glass substrate. Swelling …