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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Bioabsorbable Metal Zinc Differentially Affects Mitochondria In Vascular Endothelial And Smooth Muscle Cells, Olivia R. M. Bagshaw, Fereshteh Moradi, Christopher S. Moffatt, Hillary A. Hettwer, Ping Liang, Jeremy Goldman, Jaroslaw Drelich, Jeffrey A. Stuart
Bioabsorbable Metal Zinc Differentially Affects Mitochondria In Vascular Endothelial And Smooth Muscle Cells, Olivia R. M. Bagshaw, Fereshteh Moradi, Christopher S. Moffatt, Hillary A. Hettwer, Ping Liang, Jeremy Goldman, Jaroslaw Drelich, Jeffrey A. Stuart
Michigan Tech Publications
Zinc is an essential trace element having various structural, catalytic and regulatory interactions with an estimated 3000 proteins. Zinc has drawn recent attention for its use, both as pure metal and alloyed, in arterial stents due to its biodegradability, biocompatibility, and low corrosion rates. Previous studies have demonstrated that zinc metal implants prevent the development of neointimal hyperplasia, which is a common cause of restenosis following coronary intervention. This suppression appears to be smooth muscle cell-specific, as reendothelization of the neointima is not inhibited. To better understand the basis of zinc's differential effects on rat aortic smooth muscle (RASMC) versus …
The Effect Of Nd On Mechanical Properties And Corrosion Performance Of Biodegradable Mg-5%Zn Alloy, Lilach Elkaiam, Orly Hakimi, Jeremy Goldman, Eli Aghion
The Effect Of Nd On Mechanical Properties And Corrosion Performance Of Biodegradable Mg-5%Zn Alloy, Lilach Elkaiam, Orly Hakimi, Jeremy Goldman, Eli Aghion
Michigan Tech Publications
Mg based implants are limited by their poor strength, ductility, and corrosion performance in physiological environments, drawbacks further compounded by their premature loss of mechanical integrity and evolution of harmful hydrogen gas. Neodymium additions to magnesium have been shown to improve mechanical properties through precipitation and solid solution hardening. Therefore, the present study incorporated Nd additions (up to 3%) into a promising Mg-5%Zn-0.13%Y-0.35%Zr alloy to improve mechanical properties and corrosion resistance. The microstructure evaluation of a series of alloys was performed using optical microscopy, scanning electron microscopy (SEM), and X-ray diffraction analysis. The mechanical properties were examined in terms of …
The Suitability Of Zn–1.3% Fe Alloy As A Biodegradable Implant Material, Alon Kafri, Shira Ovadia, Jeremy Goldman, Jaroslaw W. Drelich, Eli Aghion
The Suitability Of Zn–1.3% Fe Alloy As A Biodegradable Implant Material, Alon Kafri, Shira Ovadia, Jeremy Goldman, Jaroslaw W. Drelich, Eli Aghion
Michigan Tech Publications
Efforts to develop metallic zinc for biodegradable implants have significantly advanced following an earlier focus on magnesium (Mg) and iron (Fe). Mg and Fe base alloys experience an accelerated corrosion rate and harmful corrosion products, respectively. The corrosion rate of pure Zn, however, may need to be modified from its reported ~20 µm/year penetration rate, depending upon the intended application. The present study aimed at evaluating the possibility of using Fe as a relatively cathodic biocompatible alloying element in zinc that can tune the implant degradation rate via microgalvanic effects. The selected Zn–1.3wt %Fe alloy composition produced by gravity casting …
The Prospects Of Zinc As A Structural Material For Biodegradable Implants—A Review Paper, Galit Katarivas Levy, Jeremy Goldman, Eli Aghion
The Prospects Of Zinc As A Structural Material For Biodegradable Implants—A Review Paper, Galit Katarivas Levy, Jeremy Goldman, Eli Aghion
Michigan Tech Publications
In the last decade, iron and magnesium, both pure and alloyed, have been extensively studied as potential biodegradable metals for medical applications. However, broad experience with these material systems has uncovered critical limitations in terms of their suitability for clinical applications. Recently, zinc and zinc-based alloys have been proposed as new additions to the list of degradable metals and as promising alternatives to magnesium and iron. The main byproduct of zinc metal corrosion, Zn2+, is highly regulated within physiological systems and plays a critical role in numerous fundamental cellular processes. Zn2+ released from an implant may suppress …
Formulation And Testing Of Biodegradable Polymeric Coating On Zinc Wires In Cardiovascular Stent Application, Avishan Arab Shomali
Formulation And Testing Of Biodegradable Polymeric Coating On Zinc Wires In Cardiovascular Stent Application, Avishan Arab Shomali
Dissertations, Master's Theses and Master's Reports
Biodegradable and biocompatible poly (L-lactic-acid) (PLLA) coating was applied on a modified zinc (Zn) substrate by dip coating, with the intent to delay the bio-corrosion and slow the degradation rate of zinc substrate. 3-(Trimethoxysilyl) propyl methacrylate (MPS) was used for modification of the zinc substrate for promoting the adhesion between the metallic substrate and the polymer coating. It is hypothesized that the delay in Zn biodegradation could be useful in the first several weeks to prevent the early loss of mechanical integrity of the endovascular stent and to improve the healing process of the diseased vascular site. The PLLA coating …