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Full-Text Articles in Biomedical Engineering and Bioengineering
Gas Measurement Device, Megan C. Frost, Weilue He
Gas Measurement Device, Megan C. Frost, Weilue He
Michigan Tech Patents
A device including a first chamber, a second chamber, and a membrane permeable to neutral gases but impermeable to water that is positioned between the first chamber and the second chamber. The membrane includes a first layer including PVDF and PDMS, and the PVDF has a plurality of pores at least partially filled with at least some of the PDMS.
No-Releasing Polymers And Uses Thereof, Megan C. Frost, Genevieve Romanowicz
No-Releasing Polymers And Uses Thereof, Megan C. Frost, Genevieve Romanowicz
Michigan Tech Patents
The present invention provides stable, photosensitive polymers that release NO response to intensity and wavelength of light, methods of making such polymers and methods using such polymers.
Methods For Enhancing Expression Of Secondary Cell Wall Cellulose Synthases In Plants, Chandrashekhar P. Joshi
Methods For Enhancing Expression Of Secondary Cell Wall Cellulose Synthases In Plants, Chandrashekhar P. Joshi
Michigan Tech Patents
Described are methods for making transgenic plants capable of expressing secondary cell wall cellulose synthases and methods of enhancing expression of secondary cell wall cellulose synthases in plants. Also described are plants produced by the methods. Plants comprising at least three exogenous polynucleotides encoding secondary cell wall cellulose synthases are also provided.
Methods Of Using Black Bear Parathyroid Hormone, Seth W. Donahue
Methods Of Using Black Bear Parathyroid Hormone, Seth W. Donahue
Michigan Tech Patents
Black bear parathyroid hormone (PTH) and functional fragments thereof are provided. Also provided are methods of using black bear PTH and functional fragments for increasing cAMP in a bone-forming cell; reducing apoptosis in a boneforming cell; decreasing the ratio of expression levels of Bax protein to Bcl-2 protein in a bone-forming cell; increasing the expression level of one or more of a bone matrix protein, a transcriptional activator, or a transcriptional regulator in a bone-forming cell; enhancing bone mineral density, increasing bone mass, decreasing bone loss, or reducing the incidence of bone fractures, or any combination thereof, in a subject; …
Automated Polysomnographic Assessment For Rapid Eye Movement Sleep Behavior Disorder, Joseph W. Burns, Ronald D. Chervin
Automated Polysomnographic Assessment For Rapid Eye Movement Sleep Behavior Disorder, Joseph W. Burns, Ronald D. Chervin
Michigan Tech Patents
Methods and systems for diagnosing or assessing rapid eye movement sleep behavior disorder (RBD). Muscle tone or activity variance during rapid eye movement (REM) and nonrapid eye movement (NREM) sleep intervals of a polysom- nogram are compared. A threshold based on the NREM data is used to identify a subj ect-specific threshold for abnormality in the REM variance. A metric that includes the percentage of REM variance exceeding the threshold relates to RBD.
Cell Culture Method And Apparatus For Mechanically Stimulating Cells, Seth W. Donahue
Cell Culture Method And Apparatus For Mechanically Stimulating Cells, Seth W. Donahue
Michigan Tech Patents
A cell culture assembly and a method for culturing cells that provide mechanical stimulation to cells. The cell culture assembly can include a flow chamber positioned in a fluid path and a support comprising cells positioned within the flow chamber to expose the cells to the fluid path. The cell culture assembly can further include a means for producing a steady flow of fluid in the fluid path, and a means for producing an oscillatory flow of fluid in the fluid path simultaneously with producing the steady flow of fluid in the fluid path to mechanically stimulate the cells. The …
Isolated Cellulose Synthase Promoter Regions, Chandrashekhar P. Joshi
Isolated Cellulose Synthase Promoter Regions, Chandrashekhar P. Joshi
Michigan Tech Patents
The invention relates to methods of inducing expression of coding sequences including cellulose synthase coding sequences in transgenic plants using promoters of cellulose synthase genes from Populus plant species and transgenic plants produced by the methods.
Genetic Engineering Of Syringyl-Enriched Lignin In Plants, Vincent Lee C. Chiang, Laigeng Li
Genetic Engineering Of Syringyl-Enriched Lignin In Plants, Vincent Lee C. Chiang, Laigeng Li
Michigan Tech Patents
The present invention relates to a novel DNA sequence, which encodes a previously unidentified lignin biosynthetic pathway enzyme, sinapyl alcohol dehydrogenase (SAD) that regulates the biosynthesis of syringyl lignin in plants. Also provided are methods for incorporating this novel SAD gene sequence or substantially similar sequences into a plant genome for genetic engineering of syringyl-enriched lignin in plants.
Method And Apparatus For Blood Flow Measurement Using Millimeter Wave Band, David Nelson
Method And Apparatus For Blood Flow Measurement Using Millimeter Wave Band, David Nelson
Michigan Tech Patents
A system and method that determines a blood flow rate in an area of a subject. The system includes a transmitter operable to transmit an electrical signal in the range of about 20 GHz to about 300 GHz to the area, a temperature sensor positioned adjacent the area, and a processor operable to determine the blood flow rate in the area based on the rate of change of temperature in the area as a result of the application of the electrical signal on the area and a power density value.
Application Of Aspen Mads-Box Genes To Alter Reproduction And Development In Trees, Gopi Krishna Podila, Leland James Cseke, Banalata Sen, David F. Karnosky
Application Of Aspen Mads-Box Genes To Alter Reproduction And Development In Trees, Gopi Krishna Podila, Leland James Cseke, Banalata Sen, David F. Karnosky
Michigan Tech Patents
The present invention provides compositions and methods for producing a transgenic plant that exhibits altered characteristics resulting from over expression or under expression of a novel polypeptide PtM3 or its homolog PtM4. The altered characteristics resulting from over-expression include at least one of the ability to convert axillary mer- istem to floral meristem; to accelerate flowering i.e., early flowering; to increase fruit production; to increase nut production; to increase seed output; to increase branching; to increase flower production; to increase fruit yield; to increase flower yield and a combination thereof. The altered characteristics resulting from suppressed expression include at least …
Genetic Engineering Of Plants Through Manipulation Of Lignin Biosynthesis, Vincent Lee C. Chiang, Chung-Jui Tsai, Wen-Jing Hu
Genetic Engineering Of Plants Through Manipulation Of Lignin Biosynthesis, Vincent Lee C. Chiang, Chung-Jui Tsai, Wen-Jing Hu
Michigan Tech Patents
The invention pertains to the genetically down regulating a lignin pathway p-coumarate Co-enzyme A ligase (CCL) in trees.
Plants Having Modified Reproductive Capacity, Gopi Krishna Podila, Jun-Jun Liu, David F. Karnosky
Plants Having Modified Reproductive Capacity, Gopi Krishna Podila, Jun-Jun Liu, David F. Karnosky
Michigan Tech Patents
This invention relates to plants having modified reproductive capacity. In particular, it relates to a plant reproductive tissue specific promoter, the PrAGl promoter isolated from Pinus radiata, and its use in promoting transcription/ expression of associated sequences in plant reproductive tissue, including for the purpose of producing plants which have diminished reproductive capacity or which are sterile.
Methods For Simultaneous Control Of Lignin Content And Composition, And Cellulose Content In Plants, Vincent Lee C. Chiang, Laigeng Li
Methods For Simultaneous Control Of Lignin Content And Composition, And Cellulose Content In Plants, Vincent Lee C. Chiang, Laigeng Li
Michigan Tech Patents
The present invention relates to a method of concurrently introducing multiple genes into plants and trees is provided. The method includes simultaneous transformation of plants with multiple genes from the phenylpropanoid pathways including 4CL, CAld5H, AldOMT, SAD and CAD genes and combinations thereof to produce various lines of transgenic plants displaying altered agronomic traits. The agronomic traits of the plants are regulated by the orientation of the specific genes and the selected gene combinations, which are incorporated into the plant genome.
Genetic Engineering Of Syringyl-Enriched Lignin In Plants, Vincent Lee C. Chiang, Laigeng Li
Genetic Engineering Of Syringyl-Enriched Lignin In Plants, Vincent Lee C. Chiang, Laigeng Li
Michigan Tech Patents
The present invention relates to a novel DNA sequence, which encodes a previously unidentified lignin biosynthetic pathway enzyme, sinapyl alcohol dehydrogenase (SAD) that regulates the biosynthesis of syringyl lignin in plants. Also provided are methods for incorporating this novel SAD gene sequence or substantially similar sequences into a plant genome for genetic engineering of syringyl-enriched lignin in plants.
Methods Of Modifying Lignin In Plants By Transformation With A 4-Coumarate Coenzyme A Ligase Nucleic Acid, Vincent Lee C. Chiang, Chung-Jui Tsai, Wen-Jing Hu
Methods Of Modifying Lignin In Plants By Transformation With A 4-Coumarate Coenzyme A Ligase Nucleic Acid, Vincent Lee C. Chiang, Chung-Jui Tsai, Wen-Jing Hu
Michigan Tech Patents
The invention pertains to methods of altering growth, lignin content, coniferyl and sinapyl alcohol units in the lignin structure, disease resistance and cellulose content in plants by transformation with a lignin pathway p-coumarate Co-enzyme A ligase (4CL) nucleic acid.
Spinal Fixation System, Matthew N. Songer, Jeffrey D. Vlahos, Thomas S. Kilpela, Gopal Jayaraman
Spinal Fixation System, Matthew N. Songer, Jeffrey D. Vlahos, Thomas S. Kilpela, Gopal Jayaraman
Michigan Tech Patents
An implantable, spinal, vertebral replacement device comprises a tubular cage for fitting into a space left by a missing vertebral body and for optionally retaining bone graft material. First and second transverse plates are respectively positioned at opposed ends of the tubular cage for supporting the respective cage ends and for pressing a plate face against an adjacent vertebral body in spinal columnsupporting relation. The transverse plates are each joined in transverse relation to at least one vertebral attachment plate which, in use, extends generally parallel to the spine. The vertebral attachment plate defines screw holes for screw securance to …
Genetic Transformation And Regeneration Of Plants, Vincent Lee C. Chiang, Chung-Jui Tsai, Gopi K. Podila
Genetic Transformation And Regeneration Of Plants, Vincent Lee C. Chiang, Chung-Jui Tsai, Gopi K. Podila
Michigan Tech Patents
An Agrobacterium-mediated transformation and regeneration method for plants including a transformation method to produce transgenic plants with an altered lignin composition.
Genetic Engineering Of Wood Color In Plants, Vincent Lee C. Chiang, Chung-Jui Tsai, Gopi K. Podila
Genetic Engineering Of Wood Color In Plants, Vincent Lee C. Chiang, Chung-Jui Tsai, Gopi K. Podila
Michigan Tech Patents
The invention relates to genetically engineering the wood color of woody plants by incorporation of the lignin pathway gene O-methyltransferase into the genome of the plants.
Biocidal Treatment Of Materials With Catechins, Peter E. Laks
Biocidal Treatment Of Materials With Catechins, Peter E. Laks
Michigan Tech Patents
Sulfide derivatives of catechins derived from condensed tannins have broad spectrum biocidal characteristics. Epicatechin-4-alkylsulfides and cupric complexes thereof containing up to 20, preferably 5 to 15, carbon atoms are particularly effective biocides against wood rotting fungi and gram-positive bacteria. Such sulfides are prepared by reacting condensed tannin, either in the form of a purified tannin extract or comminuted plant tissue, with an appropriate thiol under mild acidic conditions.
Biocidal Derivatives Of Catechins, Peter E. Laks
Biocidal Derivatives Of Catechins, Peter E. Laks
Michigan Tech Patents
Sulfide derivatives of catechins derived from condensed tannins have broad spectrum biocidal characteristics. Epicatechin-4-alkylsulfides and cupric complexes thereof containing up to 20, preferably 5 to 15, carbon atoms are particularly effective biocides against wood rotting fungi and gram-positive bacteria. Such sulfides are prepared by reacting condensed tannin, either in the form of a purified tannin extract or comminuted plant tissue, with an appropriate thiol under mild acidic conditions.
Carminomycin Analogue, Hassan S. El Khadem, David L. Swartz
Carminomycin Analogue, Hassan S. El Khadem, David L. Swartz
Michigan Tech Patents
A novel anthracycline glycoside 2-deoxy-L-fucopyranosyl carminomycinone which is effective for inhibiting the growth of tumors such as leukemia L1210.