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Biomedical Engineering and Bioengineering Commons™
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- 3D nanostructures (1)
- Acrylic acid (1)
- Adhesive polymers (1)
- Adhesives (1)
- Biomaterials (1)
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- Biomedical applications (1)
- Biomimetic design (1)
- Biopolymers (1)
- Catechol-boronate complexation (1)
- Dopa (1)
- Electrospinning (1)
- Mussel foot proteins (1)
- Nanofibers (1)
- Reversible adhesion (1)
- Scaffolds (1)
- Smart adhesive (1)
- Soft actuators (1)
- Tissue adhesives (1)
- Tissue engineering (1)
- Tough hydrogels (1)
- Wet adhesion (1)
Articles 1 - 5 of 5
Full-Text Articles in Biomedical Engineering and Bioengineering
Self-Assembly Of 3d Nanostructures In Electrospun Polycaprolactone-Polyaniline Fibers And Their Application As Scaffolds For Tissue Engineering, Samerender Nagam Hanumantharao, Carolynn Que, Smitha Rao
Self-Assembly Of 3d Nanostructures In Electrospun Polycaprolactone-Polyaniline Fibers And Their Application As Scaffolds For Tissue Engineering, Samerender Nagam Hanumantharao, Carolynn Que, Smitha Rao
Department of Biomedical Engineering Publications
The fabrication of synthetic scaffolds that mimic the microenvironment of cells is a crucial challenge in materials science. The honeycomb morphology is one such bio-mimicking structure that possesses unique physical properties and high packing efficiency in a 3-dimensional space. Here, we present a novel method for electrospinning polycaprolactone-polyaniline with continuous, self-assembled, uniform, interwoven nanofibers forming patterns without the use of templates or porogens. By using the approach presented here, unique architectures mimicking the natural mechanical anisotropy of extracellular matrix were created by varying the electric field. Adult human dermal fibroblasts (HDFa) cells were successfully cultured on the nanofiber scaffolds without …
Incorporation Of Anionic Monomer To Tune The Reversible Catechol-Boronate Complex For Ph Responsive, Reversible Adhesion, Ameya R. Narkar, Bruce P. Lee
Incorporation Of Anionic Monomer To Tune The Reversible Catechol-Boronate Complex For Ph Responsive, Reversible Adhesion, Ameya R. Narkar, Bruce P. Lee
Department of Biomedical Engineering Publications
Up to 30 mol% of acrylic acid (AAc) was incorporated into a pH responsive smart adhesive consisting of dopamine methacrylamide (DMA) and 3-acrylamido phenylboronic acid (APBA). FTIR spectroscopy and rheometry confirmed that the incorporation of AAc shifted the pH of catechol-boronate complexation to a more basic pH. Correspondingly, adhesive formulations with elevated AAc contents demonstrated strong adhesion to quartz substrate at a neutral to mildly basic pH (pH 7.5-8.5) based on Johnson-Kendall-Roberts (JKR) contact mechanics test. When pH was further increased to pH 9.0, there was a drastic reduction in the measured work of adhesion (18 and 7 fold reduction …
Recent Developments In Tough Hydrogels For Biomedical Applications, Yuan Liu, Weilue He, Zhongtian Zhang, Bruce P. Lee
Recent Developments In Tough Hydrogels For Biomedical Applications, Yuan Liu, Weilue He, Zhongtian Zhang, Bruce P. Lee
Department of Biomedical Engineering Publications
A hydrogel is a three-dimensional polymer network with high water content and has been attractive for many biomedical applications due to its excellent biocompatibility. However, classic hydrogels are mechanically weak and unsuitable for most physiological load-bearing situations. Thus, the development of tough hydrogels used in the biomedical field becomes critical. This work reviews various strategies to fabricate tough hydrogels with the introduction of non-covalent bonds and the construction of stretchable polymer networks and interpenetrated networks, such as the so-called double-network hydrogel. Additionally, the design of tough hydrogels for tissue adhesive, tissue engineering, and soft actuators is reviewed.
Recent Approaches In Designing Bioadhesive Materials Inspired By Mussel Adhesive Protein, Pegah Kord Forooshani, Bruce P. Lee
Recent Approaches In Designing Bioadhesive Materials Inspired By Mussel Adhesive Protein, Pegah Kord Forooshani, Bruce P. Lee
Department of Biomedical Engineering Publications
Marine mussels secret protein-based adhesives, which enable them to anchor to various surfaces in a saline, intertidal zone. Mussel foot proteins (Mfps) contain a large abundance of a unique, catecholic amino acid, Dopa, in their protein sequences. Catechol offers robust and durable adhe-sion to various substrate surfaces and contributes to the curing of the adhesive plaques. In this article, we review the unique features and the key functionalities of Mfps, catechol chemistry, and strategies for preparing catechol-functionalized poly- mers. Specifically, we reviewed recent findings on the contributions of various features of Mfps on interfacial binding, which include coacervate formation, surface …
Fibrin Gel As An Injectable Biodegradable Scaffold And Cell Carrier For Tissue Engineering, Yuting Li, Hao Meng, Yuan Liu, Bruce P. Lee
Fibrin Gel As An Injectable Biodegradable Scaffold And Cell Carrier For Tissue Engineering, Yuting Li, Hao Meng, Yuan Liu, Bruce P. Lee
Department of Biomedical Engineering Publications
Due to the increasing needs for organ transplantation and a universal shortage of donated tissues, tissue engineering emerges as a useful approach to engineer functional tissues. Although different synthetic materials have been used to fabricate tissue engineering scaffolds, they have many limitations such as the biocompatibility concerns, the inability to support cell attachment, and undesirable degradation rate. Fibrin gel, a biopolymeric material, provides numerous advantages over synthetic materials in functioning as a tissue engineering scaffold and a cell carrier. Fibrin gel exhibits excellent biocompatibility, promotes cell attachment, and can degrade in a controllable manner. Additionally, fibrin gel mimics the natural …