Biomedical Engineering and Bioengineering Commons^™

Quantifying Shear Stresses In Tissue Engineered Aortic Heart Valves, Raj Nitin Dave

All Theses

Present heart valve prosthesis have limitations such as capability to grow, repair and remodel post implantation. Tissue engineering offers to be a promising alternative to overcome these limitations. Maturation of seeded human cells on the valve subjected to favorable growth conditions in the bioreactor is critical to the success of tissue engineered heart valves. Mechanical stress and strain which results from the pressure and flow conditions in the bioreactor plays a critical role on the developing valve tissue and are currently unknown. The goal of this research is to relate the magnitude of wall shear stress (WSS) within the heart …

Cardiovascular Biomechanical Models, Ethan Kung

Publications

Computational and in vitro methods offer powerful means to model the cardiovascular system and investigate biomechanics related to blood flow, cardiovascular tissue, and medical devices. These models can be constructed to directly describe human anatomy and physiology, and can be more highly controlled compared to animal models. Low-order models composed of lumped-parameter elements and simplified descriptions of cardiac function can capture the global physiology, while high-order models exhibiting detailed 3D anatomy and dynamics can provide highly realistic replication of biomechanical interactions in a small region of the circulation. Multiscale models offer the freedom to capture biomechanics in different regions at …

In Vitro Validation Of Patient-Specific Hemodynamic Simulations In Coronary Aneurysms Caused By Kawasaki Disease, Ethan Kung, Andrew M. Kahn, Jane C. Burns, Alison Marsden

Publications

To perform experimental validation of computational fluid dynamics (CFD) applied to patient specific coronary aneurysm anatomy of Kawasaki disease. We quantified hemodynamics in a patient-specific coronary artery aneurysm physical phantom under physiologic rest and exercise flow conditions. Using phase contrast MRI (PCMRI), we acquired 3-component flow velocity at two slice locations in the aneurysms. We then performed numerical simulations with the same geometry and inflow conditions, and performed qualitative and quantitative comparisons of velocities between experimental measurements and simulation results. We observed excellent qualitative agreement in flow pattern features. The quantitative spatially and temporally varying differences in velocity between PCMRI …

Predictive Modeling Of The Virtual Hemi-Fontan Operation For Second Stage Single Ventricle Palliation: Two Patient-Specific Cases, Ethan Kung, Alessia Baretta, Catriona Baker, Gregory Arbia, Giovanni Biglino, Chiara Corsini, Silvia Schievano, Irene E. Vignon-Clementel, Gabriele Dubini, Giancarlo Pennati, Andrew Taylor, Adam Dorfman, Anthony M. Hlavacek, Alison L. Marsden, Tain-Yen Hsia, Francesco Migliavacca

Publications

Single ventricle hearts are congenital cardiovascular defects in which the heart has only one functional pumping chamber. The treatment for these conditions typically requires a three-staged operative process where Stage 1 is typically achieved by a shunt between the systemic and pulmonary arteries, and Stage 2 by connecting the superior venous return to the pulmonary circulation. Surgically, the Stage 2 circulation can be achieved through a procedure called the Hemi-Fontan, which reconstructs the right atrium and pulmonary artery to allow for an enlarged confluence with the superior vena cava.

Based on pre-operative data obtained from two patients prior to Stage …