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Full-Text Articles in Biomedical Engineering and Bioengineering
Target Flow-Pressure Operating Range For Designing A Failing Fontan Cavopulmonary Support Device, Masoud Farahmand, Minoo N. Kavarana, Phillip M. Trusty, Ethan Kung
Target Flow-Pressure Operating Range For Designing A Failing Fontan Cavopulmonary Support Device, Masoud Farahmand, Minoo N. Kavarana, Phillip M. Trusty, Ethan Kung
Publications
Fontan operation as the current standard of care for the palliation of single ventricle defects results in significant late complications. Using a mechanical circulatory device for the right circulation to serve the function of the missing subpulmonary ventricle could potentially stabilize the failing Fontan circulation. This study aims to elucidate the hydraulic operating regions that should be targeted for designing cavopulmonary blood pumps. By integrating numerical analysis and available clinical information, the interaction of the cavopulmonary support via the IVC and full assist configurations with a wide range of simulated adult failing scenarios was investigated; with IVC and full assist …
High Gravity Fermentation Of Sugarcane Bagasse Hydrolysate By Saccharomyces Pastorianus To Produce Economically Distillable Ethanol Concentrations: Necessity Of Medium Components Examined, Sarah W. Harcum, Thomas P. Caldwell
High Gravity Fermentation Of Sugarcane Bagasse Hydrolysate By Saccharomyces Pastorianus To Produce Economically Distillable Ethanol Concentrations: Necessity Of Medium Components Examined, Sarah W. Harcum, Thomas P. Caldwell
Open Access Publishing Fund
A major economic obstacle in lignocellulosic ethanol production is the low sugar concentrations in the hydrolysate and subsequent fermentation to economically distillable ethanol concentrations. We have previously demonstrated a two-stage fermentation process that recycles xylose with xylose isomerase to increase ethanol productivity, where the low sugar concentrations in the hydrolysate limit the final ethanol concentrations. In this study, three approaches are combined to increase ethanol concentrations. First, the medium-additive requirements were investigated to reduce ethanol dilution. Second, methods to increase the sugar concentrations in the sugarcane bagasse hydrolysate were undertaken. Third, the two-stage fermentation process was recharacterized with high gravity …
Risks And Benefits Of Using A Commercially Available Ventricular Assist Device For Failing Fontan Cavopulmonary Support: A Modeling Investigation, Masoud Farahmand, Minoo N. Kavarana, Ethan Kung
Risks And Benefits Of Using A Commercially Available Ventricular Assist Device For Failing Fontan Cavopulmonary Support: A Modeling Investigation, Masoud Farahmand, Minoo N. Kavarana, Ethan Kung
Publications
Fontan patients often develop circulatory failure and are in desperate need of a therapeutic solution. A blood pump surgically placed in the cavopulmonary pathway can substitute the function of the absent sub-pulmonary ventricle by generating a mild pressure boost. However, there is currently no commercially available device designed for the cavopulmonary application; and the risks and benefits of implanting a ventricular assist device (VAD), originally designed for the left ventricular application, on the right circulation of failing Fontan patients is not yet clear. Moreover, further research is needed to compare the hemodynamics between the two clinically-considered surgical configurations for cavopulmonary …