Biomedical Engineering and Bioengineering Commons^™

Silica Formation With Nanofiber Morphology Via Helical Display Of The Silaffin R5 Peptide On A Filamentous Bacteriophage, In-Wong Song, Hyojung Park, Jung Han Park, Hyunook Kim, Seong Hun Kim, Justyn Jaworski, Byoung-In Sang, Sung Yi

Bioengineering Faculty Publications

Biological systems often generate unique and useful structures, which can have industrial relevance either as direct components or as an inspiration for biomimetic materials. For fabrication of nanoscale silica structures, we explored the use of the silaffin R5 peptide from Cylindrotheca fusiformis expressed on the surface of the fd bacteriophage. By utilizing the biomineralizing peptide component displayed on the bacteriophage surface, we found that low concentrations (0.09 mg/mL of the R5 bacteriophage, below the concentration range used in other studies) could be used to create silica nanofibers. An additional benefit of this approach is the ability of our R5-displaying phage …