Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
Articles 1 - 4 of 4
Full-Text Articles in Biomedical Engineering and Bioengineering
Visuomotor Learning Enhanced By Augmenting Instantaneous Trajectory Error Feedback During Reaching, James Patton, John Yejun, Preeti Bajaj, Robert Scheidt
Visuomotor Learning Enhanced By Augmenting Instantaneous Trajectory Error Feedback During Reaching, James Patton, John Yejun, Preeti Bajaj, Robert Scheidt
Robert Scheidt
We studied reach adaptation to a 30u visuomotor rotation to determine whether augmented error feedback can promote faster and more complete motor learning. Four groups of healthy adults reached with their unseen arm to visual targets surrounding a central starting point. A manipulandum tracked hand motion and projected a cursor onto a display immediately above the horizontal plane of movement. For one group, deviations from the ideal movement were amplified with a gain of 2 whereas another group experienced a gain of 3.1. The third group experienced an offset equal to the average error seen in the initial perturbations, while …
Visuo-Proprioceptive Interactions During Adaptation Of The Human Reach, Timothy Judkins, Robert Scheidt
Visuo-Proprioceptive Interactions During Adaptation Of The Human Reach, Timothy Judkins, Robert Scheidt
Robert Scheidt
We examined whether visual and proprioceptive estimates of transient (mid-reach) target capture errors contribute to motor adaptation according to the probabilistic rules of information integration used for perception. Healthy adult humans grasped and moved a robotic handle between targets in the horizontal plane while the robot generated spring-like loads that varied unpredictably from trial-to-trial. For some trials, a visual cursor faithfully tracked hand motion. In others, the handle's position was locked and subjects viewed motion of a point-mass cursor driven by hand forces. In yet other trials, cursor feedback was dissociated from hand motion or altogether eliminated. We used time- …
Human Coronary Plaque Wall Thickness Correlated Positively With Flow Shear Stress And Negatively With Plaque Wall Stress: An Ivus-Based Fluid-Structure Interaction Multi-Patient Study, Kristen Billiar, Rui Fan, Dalin Tang, Chun Yang, Jie Zheng, Richard Bach, Liang Wang, David Muccigrosso, Jian Zhu, Genshan Ma, Akiko Maehara, Gary Mintz
Human Coronary Plaque Wall Thickness Correlated Positively With Flow Shear Stress And Negatively With Plaque Wall Stress: An Ivus-Based Fluid-Structure Interaction Multi-Patient Study, Kristen Billiar, Rui Fan, Dalin Tang, Chun Yang, Jie Zheng, Richard Bach, Liang Wang, David Muccigrosso, Jian Zhu, Genshan Ma, Akiko Maehara, Gary Mintz
Kristen L. Billiar
BACKGROUND: Atherosclerotic plaque progression and rupture are believed to be associated with mechanical stress conditions. In this paper, patient-specific in vivo intravascular ultrasound (IVUS) coronary plaque image data were used to construct computational models with fluid-structure interaction (FSI) and cyclic bending to investigate correlations between plaque wall thickness and both flow shear stress and plaque wall stress conditions. METHODS: IVUS data were acquired from 10 patients after voluntary informed consent. The X-ray angiogram was obtained prior to the pullback of the IVUS catheter to determine the location of the coronary artery stenosis, vessel curvature and cardiac motion. Cyclic bending was …
Expression And Differentiation Between Oct4a And Its Pseudogenes In Human Escs And Differentiated Adult Somatic Cells., Sakthikumar Ambady, Mojca Jez, Olga Kashpur, Alexandra Grella, Christopher Malcuit, Lucy Vilner, Primoz Rozman, Tanja Dominko
Expression And Differentiation Between Oct4a And Its Pseudogenes In Human Escs And Differentiated Adult Somatic Cells., Sakthikumar Ambady, Mojca Jez, Olga Kashpur, Alexandra Grella, Christopher Malcuit, Lucy Vilner, Primoz Rozman, Tanja Dominko
Sakthikumar Ambady
The POU5F1 gene codes for the OCT4 transcription factor, which is one of the key regulators of pluripotency. Its transcription, alternative splicing, and alternative translation leading to the synthesis of the active, nuclear localized OCT4A has been described in detail. Much less, however, is known about actively transcribed OCT4 pseudogenes, several of which display high homology to OCT4A and can be expressed and translated into proteins. Using RT-PCR followed by pseudogene-specific restriction digestion, cloning, and sequencing we discriminate between OCT4A and transcripts for pseudogenes 1, 3 and 4. We show that expression of OCT4 and its pseudogenes follows a developmentally-regulated …