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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Covalently Crosslinked Organic/Inorganic Hybrid Biomaterials For Bone Tissue Engineering Applications, Dibakar Mondal
Covalently Crosslinked Organic/Inorganic Hybrid Biomaterials For Bone Tissue Engineering Applications, Dibakar Mondal
Electronic Thesis and Dissertation Repository
Scaffolds are key components for bone tissue engineering and regeneration. They guide new bone formation by mimicking bone extracellular matrix for cell recruitment and proliferation. Ideally, scaffolds for bone tissue engineering need to be osteoconductive, osteoinductive, porous, degradable and mechanically competent. As a single material can not provide all these requirements, composites of several biomaterials are viable solutions to combine various properties. However, conventional composites fail to fulfil these requirements due to their distinct phases at the microscopic level. Organic/inorganic (O/I) class II hybrid biomaterials, where the organic and inorganic phases are chemically crosslinked on a molecular scale, hence the …
Modulation Of Bone And Nerve Cell Behavior Using Biodegradable Polymer Networks, Lei Cai
Modulation Of Bone And Nerve Cell Behavior Using Biodegradable Polymer Networks, Lei Cai
Doctoral Dissertations
This dissertation presents novel biodegradable and photo-crosslinkable building blocks to achieve polymer networks with controlled surface chemistry, stiffness, and topographical features for investigating cell-material interactions and targeting hard and soft tissue engineering applications. Chapter I reviews the recent progress in polymeric gel systems and how their physical properties can be tailored to regulate cell functions and satisfy the clinical needs. Chapter II presents a facile method to synthesize photo-crosslinkable poly(epsilon-caprolactone) acrylates (PCLAs) and reveal tunable cell responses to photo-crosslinked PCLAs. Chapter III investigates the mechanism of colorization in preparing crosslinkable polymers by reacting hydroxyl-containing polymers with unsaturated anhydrides or acyl …
Electrospun Polycaprolactone Nanofiber Scaffolds For Tissue Engineering, Andreas Haukas
Electrospun Polycaprolactone Nanofiber Scaffolds For Tissue Engineering, Andreas Haukas
Graduate Theses and Dissertations
Stem cell and tissue engineering offer us with a unique opportunity to research and develop new therapies for treating various diseases that are otherwise incurable using traditional medicines. However, development of these new therapies replies upon the establishment of in vitro cell culture and differentiation systems that mimic in vivo microenvironments required for cell-cell and cell-ECM interaction. The development of these cell culture systems depends upon the identification of appropriate biomaterials and cell sources. Biomaterials should be carefully selected and fabricated into scaffolds for supporting cell growth and differentiation. In this study, we explored the fabrication of 3D electrospun nanofiber …