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A Study Of Osteocyte Apoptosis By Region And Quadrant In Murine Cortical Bone, Jessica Kristen Chan
A Study Of Osteocyte Apoptosis By Region And Quadrant In Murine Cortical Bone, Jessica Kristen Chan
Master's Theses
ABSTRACT
A Study of Osteocyte Apoptosis by Region and Quadrant in Murine Cortical Bone
Jessica Kristen Chan
Osteocytes undergo apoptosis to spatially and temporally initiate bone remodeling. This study investigates the distribution of apoptotic osteocytes within different quadrants and regions of cortical bone and compares the frequency of osteocyte apoptosis to regional factors associated with bone remodeling. Specifically, the quantity of apoptosis was compared to levels of the bone morphagenic protein antagonists noggin and gremlin. Samples of unloaded right tibial bone obtained from C57/Bl/6 mice underwent TUNEL staining for apoptotic osteocytes and were counterstained with methyl green to detect osteocyte …