Biomedical Engineering and Bioengineering Commons^™

Photonic Crystal Hydrogels: Simulation, Fabrication & Biomedical Application, Mehenur Sarwar

FIU Electronic Theses and Dissertations

Photonic crystal (PhC) hydrogels are a unique class of material that has tremendous promise as biomedical sensors. The underlying crystal structure allows for simple analysis of microstructural properties by assessing the diffraction pattern generated following laser illumination. The hydrogel medium provides elasticity, regenerability, and potential functionalization. Combining these two properties, photonic crystal hydrogels have the potential for sensing physical forces and chemical reagents using a low-cost, reusable platform.

The development of biomedical sensors using this material is limited due to the lack of a method to accurately predict the diffraction pattern generated. To overcome this, a computational model was developed …

Application Of Limited Mixing In The Hele-Shaw Geometry In Fabrication Of Janus Hydrogels, Md Mahmudur Rahman

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

It is widely accepted that cells behave differently responding to the stiffness of their extracellular matrix (ECM). Such observations were made by culturing cells on hydrogel substrates of tunable stiffness. However, it was recently proposed that cells may sense how strongly they are tethered to ECM, not the local stiffness of ECM. To investigate both hypotheses, we developed a method to fabricate Janus polyacrylamide (PAAM) gels. We squeeze two drops of different concentrations in the Hele-Shaw geometry to generate radial Stokes flow. When the drops coalesce, limited mixing occurs at the interface due to the narrow confinement, and diffusion normal …