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Full-Text Articles in Biomedical Engineering and Bioengineering
The Utilization Of Autofluorescence To Study The Effects Of L-Buthionine-Sulfoximine On Cellular Metabolism In Vitro, Madison Belew
The Utilization Of Autofluorescence To Study The Effects Of L-Buthionine-Sulfoximine On Cellular Metabolism In Vitro, Madison Belew
Biomedical Engineering Undergraduate Honors Theses
Oxidative damage and stress impacts metabolic activity and has been implicated in a number of diseases . These medical conditions have been found to be associated with a lack of glutathione (GSH). There is a need to study the effects that the absence of glutathione has in order to expand knowledge of indicators that cause conditions like cataracts, cancer, or impaired wound healing. L-buthionine-sulfoximine (BSO) has been used in past studies to hinder GSH production and induce oxidative stress within a cell. This study explores the effects of BSO and induced oxidative stress on the metabolic activity and processes within …
Theoretical Applicability Of Crispr-Mediated Exon Skipping In Duchenne Muscular Dystrophy, Andrew Greek
Theoretical Applicability Of Crispr-Mediated Exon Skipping In Duchenne Muscular Dystrophy, Andrew Greek
Biomedical Engineering Undergraduate Honors Theses
Duchenne muscular dystrophy (DMD) affects approximately 1 in 5,000 males. DMD results from genetic mutations within the gene that interrupts the open reading frame and prematurely truncates the protein. From a non-functional dystrophin protein, DMD results in serious muscle weakening and muscle wasting ultimately leading to death around the age of 26. In some cases of muscular dystrophy, a mutation can occur in areas of the gene that are less essential. In Becker muscular dystrophy (BMD), these mutations cause less significant consequences in phenotype as the dystrophin protein is still semi-functional. With gene editing techniques, it may be possible to …