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Understanding The Role Of Antioxidant Nanoparticles In Improving The Outcome Of Secondary Injury In Traumatic Brain Injury, Aria W. Tarudji
Understanding The Role Of Antioxidant Nanoparticles In Improving The Outcome Of Secondary Injury In Traumatic Brain Injury, Aria W. Tarudji
Department of Biological Systems Engineering: Dissertations and Theses
Following traumatic brain injury (TBI), excess reactive oxygen species (ROS) and other free radicals are released, inducing the cascade of secondary injury that exacerbate the outcomes of TBI. Antioxidant nanoparticles (ANPs) have shown promising outcomes in reducing the progression of TBI, which may be due to the higher accumulation and retention of ANPs in the injured brain. However, there is limited knowledge of: 1) antioxidant activities needed in TBI treatment, 2) correlation between longer retention, bioavailability, and target engagement with antioxidant treatments, and 3) sexual dimorphism to ANP treatments.
This dissertation assesses multiple ANPs with various scavenging activities and durations …