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Full-Text Articles in Biomedical Engineering and Bioengineering
Design Of Experimentation To Systematically Determine The Interaction Between Electrospinning Variables And To Optimize The Fiber Diameter Of Electrospun Poly (D, L-Lactide-Co-Glycolide) Scaffolds For Tissue Engineered Constructs, Yvette S. Castillo
Master's Theses
Cardiac disease causes approximately a third of the deaths in the United States. Furthermore, most of these deaths are due to a condition termed atherosclerosis, which is a buildup of plaque in the coronary arteries, leading to occlusion of normal blood flow to the cardiac muscle. Among the methods to treat the condition, stents are devices that are used to restore normal blood flow in the atherosclerotic arteries. Before advancement can be made to these devices and changes can be tested in live models, a reliable testing method that mimics the environment of the native blood vessel is needed. Dr. …
Co-Culture Of Smooth Muscle Cells And Endothelial Cells On Porous 3d Polyurethane Scaffolds For Vascular Tissue Engineering, Aparna Bhattacharyya
Co-Culture Of Smooth Muscle Cells And Endothelial Cells On Porous 3d Polyurethane Scaffolds For Vascular Tissue Engineering, Aparna Bhattacharyya
Electronic Thesis and Dissertation Repository
One of the challenges in the designing of clinically-relevant vascular substitutes is our lack of understanding on how vascular smooth muscle cells (VSMCs) and vascular endothelial cells (VECs) interact in the graft. The aim of this study was to examine the factors that play a role in VSMC and VEC interaction in 3D co-culture. Highly porous 3D poly(carbonate urethane) scaffolds were fabricated using a solvent casting and particulate leaching method. VSMCs and VECs were co-cultured for 48 hours. Immunofluorescence staining showed that VSMCs readily attached to the scaffold and formed dense confluent layers which facilitated the organization of VECs of …
Evaluation Of Decellularization Procedures For Porcine Arteries, Charles Clapp
Evaluation Of Decellularization Procedures For Porcine Arteries, Charles Clapp
Biomedical Engineering
Coronary artery disease has become the leading cause of death in the United States, with over 425,000 deaths in 2006. Stenting has evolved into the preferred preventative technique for myocardial infarction by opening up an occluded artery, due to its low invasiveness compared to the alternative of coronary artery bypass grafting. Bare metal stents have been improved by coating with anti-proliferative drugs to advance their effects, but even drug eluting stents still have a risk of restenosis, thrombus formation, and necessary revascularization. Continual advancement in stent design necessitates faster, effective pre-clinical evaluation techniques. Kristen Cardinal, Ph.D., developed the blood vessel …
A Novel In-House Design Of A Bioreactor For The Modeling Of An In Vitro Blood Brain Barrier Model, Ian Mahaffey
A Novel In-House Design Of A Bioreactor For The Modeling Of An In Vitro Blood Brain Barrier Model, Ian Mahaffey
Biomedical Engineering
The blood brain barrier is the protector of the central nervous system and a physical barrier that functions to regulate the substances that can pass in and out of the brain; it is the function and integrity of this system that keeps the homeostasis of the central nervous system. Yet this shield against foreign invaders in the blood also prevents drugs designed for treatment of various ailments of the central nervous system from reaching their target in the brain. Developing drugs that can pass through this barrier, and understanding it’s function has become an area of increasing interest. Many researchers …