Biomedical Engineering and Bioengineering Commons^™

Biomanufacturing Organized Collagen-Based Microfibers As A Tissue Engineered Device (Tend) For Tendon Regeneration, Yas Maghdouri-White, Nardos Sori, Stella Petrova, Hilary Wriggers, Nathan Kemper, Amrita Dasgupta, Kelly Coughenour, Seth Polk, Nick Thayer, Mario Rodriguez, Bill Simon, Anna Bulysheva, Kevin Bonner,, Steven Arnoczky, Samuel Adams, Michael Francis

Bioelectrics Publications

Approximately 800,000 surgical repairs are performed annually in the U.S. for debilitating injuries to ligaments and tendons of the foot, ankle, knee, wrist, elbow and shoulder, presenting a significant healthcare burden. To overcome current treatment shortcomings and advance the treatment of tendon and ligament injuries, we have developed a novel electrospun Tissue ENgineered Device (TEND), comprised of type I collagen and poly(D,L-lactide) (PDLLA) solubilized in a benign solvent, dimethyl sulfoxide (DMSO). TEND fiber alignment, diameter and porosity were engineered to enhance cell infiltration leading to promote tissue integration and functional remodeling while providing biomechanical stability. TEND rapidly adsorbs …