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Full-Text Articles in Biomedical Engineering and Bioengineering
Reprogramming And Imaging Of Tumor Associated Macrophages Using Spuramolecular Nanoparticles, Anujan Ramesh
Reprogramming And Imaging Of Tumor Associated Macrophages Using Spuramolecular Nanoparticles, Anujan Ramesh
Doctoral Dissertations
Macrophages are highly plastic cells that are a part of the mononuclear phagocytic system and play a crucial role in both the innate and the adaptive immune systems. Although they have functionally diverse roles involved in physiological and pathological processes, they primarily act as phagocytes that aid in clearing infections. During these instances of tissue injury or infections, circulating monocytes are recruited to the site of the injury, where they differentiate to give rise to macrophages that have a pro-inflammatory function. These monocytes derived macrophages, however, exist across a spectrum of phenotypes based on the local tissue environment. The two …
Elucidating Mechanisms Of Metastasis With Implantable Biomaterial Niches, Ryan Adam Carpenter
Elucidating Mechanisms Of Metastasis With Implantable Biomaterial Niches, Ryan Adam Carpenter
Doctoral Dissertations
Metastasis is the leading cause of cancer related deaths, yet it remains the most poorly understood aspect of tumor biology. This can be attributed to the lack of relevant experimental models that can recapitulate the complex and lengthy progression of metastatic relapse observed in patients. Mouse models have been widely used to study cancer, however they are critically limited to study metastasis. Most models generate aggressive metastases in the lung without the use of unique cell lines or specialized injection techniques. This limits the ability to study disseminated tumor cells (DTCs) in other relevant metastasis prone tissues. Prolonged observation of …