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Full-Text Articles in Biomedical Engineering and Bioengineering
Mesenchymal Stromal Cell And Chondrocyte Mobility In 3d Bioprinted Hydrogel Constructs, Alesia Lokshina
Mesenchymal Stromal Cell And Chondrocyte Mobility In 3d Bioprinted Hydrogel Constructs, Alesia Lokshina
Honors Undergraduate Theses
Osteoarthritis (OA) is a progressive cartilage degeneration disease with a complex pathologic mechanism. Although OA has devastating effects on patient quality of life and places a significant burden on the healthcare system, no disease-modifying drugs have been found, and surgical treatment options are often unsustainable. 3D bioprinting is a novel field within tissue engineering that focuses on developing biocompatible constructs that can be implanted to replace an organ or tissue. Such constructs have a great potential to become treatments for OA. Understanding cell mobility within hydrogels could play a vital role in advancing the development of biocompatible constructs. However, due …
Using A Lubricin Reporter Cell To Test Current Vs. Optimized Media Compositions, Sean M. Kennedy
Using A Lubricin Reporter Cell To Test Current Vs. Optimized Media Compositions, Sean M. Kennedy
Honors Undergraduate Theses
Osteoarthritis is a joint disease characterized by the breakdown of articular cartilage. The field of tissue engineering is interested in developing methods to produce biological alternatives to current orthopedic procedures. Lubricin is a molecule which is important in the proper lubrication of articular cartilage. It is a challenge in the field of tissue engineering to produce cartilage with sufficient lubricin expression. Developing a reporter cell for lubricin allowed for a more efficient investigation of the conditions which may influence its expression. By comparing "optimized" and traditional media solutions, it was determined that the use of a previously reported type II …