Biomedical Engineering and Bioengineering Commons^™

Tailoring Of The Left Ventricular Assist Device Cannula Implantation Using Coupled Multi-Scale Multi-Objective Patient Specific Optimization., Abubakar Dankano

Electronic Theses and Dissertations, 2020-

Despite advancements in device design and anti-coagulation treatments, there are numerous adverse events that may occur following implantation of LVADs. The most devastating involves the embolization of thrombus into the brain causing a stroke, with incidence of up to 14-47% over a 6–12-month period. This study aims to elucidate ways to reduce this risk by surgical maneuvers guided by a multi-scale computational fluid dynamics analysis wrapped around a multi-objective shape optimization scheme which optimizes the anastomosis location of the VAD outflow graft (OG) along the ascending aorta to minimize the incidence of thrombi reaching the cerebral vessels and reduce particle …

Visuomotor Adaptation During Asymmetric Walking, Charles Napoli

Masters Theses

Necessary for effective ambulation, head stability affords optimal conditions for the perception of visual information during dynamic tasks. This maintenance of head-in-space equilibrium is achieved, in part, by the attenuation of the high frequency impact shock resulting from ground contact. While a great deal of experimentation has been done on the matter during steady state locomotion, little is known about how head stability or dynamic visual acuity is maintained during asymmetric walking.

In this study, fifteen participants were instructed to walk on a split-belt treadmill for ten minutes while verbally reporting the orientation of a randomized Landolt-C optotype that was …

Development Of A Novel Haptic Feedback System For Gait Training Applications, Mohsen Alizadeh Noghani

Electronic Theses and Dissertations

Until recently, study and correction of motor or gait functions required costly sensors and measurement setups (e.g., optical motion capture systems) which were only available in laboratories or clinical environments. However, due to (1) the growing availability and affordability of inertial measurement units (IMUs) with high accuracy, and (2) progress in wireless, high bandwidth, and energy-efficient networking technologies such as Bluetooth Low Energy (BLE), it is now possible to measure and provide feedback in real-time for biomechanical parameters outside of those specialized settings. To enable gait training without an expert who can provide verbal feedback, augmented feedback, which is divided …

Attachment Of Fibrous Materials In Nature And Surgical Repair, Ethan Daniel Hoppe

McKelvey School of Engineering Theses & Dissertations

Mother nature is the ultimate problem solver. Often by brute force and necessity for survival, the organism that has the best solution to a problem is the one to proliferate. One of these problems for which nature provides an elegant solution is the attachment of dissimilar materials. This dissertation explores the strengthening and relaxation of interactions between soft and hard materials, typically with one of the two being fibrous in character, with the goal of identifying strategies for improving the surgical reattachment of tendon to bone. The work begins with a study of the plant Harpagonella palmeri, which the dissertation …

Biomaterial For Cervical Intervertebral Disc Prosthesis, Helium Mak

Electronic Thesis and Dissertation Repository

Recent long-term follow-up studies have shown that the cervical disc arthroplasty treatment have potentials in developing surrounding heterotopic ossification (HO). While its cause requires further investigation, this thesis has hypothesized that it may be the result of the continual remodeling of the injured vertebrae caused by the prostheses with smaller footprints introducing abnormal stresses. The research objective of this thesis is to develop a new prosthesis material that can be molded into any form conforming to the size and shape of the end-plates of the affected patient vertebrae. For prototype development, a composite material consisting of 10wt% polyvinyl alcohol cryogel …

Development Of A 7 Dof Exoskeleton Robot For Rehabilitation Of Lower Extremity, Sk Hasan

Theses and Dissertations

The World Health Organization reports that worldwide about 1 billion people have some form ofdisability. Of these, 110-190 million people have significant difficulties in functioning (mainly upper and lower extremity disability) independently. The major causes of human lower extremity disability include stroke, trauma, spinal cord injuries, and muscular dystrophy. Every 40 seconds, someone in the United States has a stroke. A statistic shows that approximately 65% of post-stroke patients suffer lower extremity impairment. Rehabilitation programs are the main method to promote functional recovery in disabled individuals. The conventional therapeutic approach requires a long commitment from a therapist or a clinician. …

Musculoskeletal Adaptation Of Young And Older Adults In Response To Environmental, Physical, And Cognitive Conditions, Amy E. Holcomb

Boise State University Theses and Dissertations

Accidental falls present a large functional and financial burden among people aged 65 years and older. Falls, injuries associated with falls, and the fear of falling decrease quality of life, physical function, and independence for older adults. To prevent falls, improve stability, and protect joints from damage or injury, the typical response to "challenging" conditions include cautious gait, increase muscle co-contraction, and decreased range of motion. These compensatory strategies are more pronounced in the older adult population with apprehensive "cautious" gait at slower speeds, decreased knee flexion, and increased muscle activation around the knee and ankle. The underlying mechanisms and …

Effect Of Obesity On Knee Joint During Walking And Squatting, Simon Vasquez Iii

Theses and Dissertations

This paper analyzes the effect of obesity on the knee joints during squats. This was performed on 2 different subjects by having each squat 30 times at their decided comfortable depth to display some fatigue and effects on the knee joints. Using the VICON NEXUS and AMTI force plates equipment at The University of Texas at Rio Grande Valley Biomechanics Lab, the center of pressure, knee flexion angles, velocity, and ground reaction forces were calculated. The subjects performed the exercises with and without additional weight using a body vest and kettlebell. The ground reaction forces showed a significant increase in …

Development Of A Wireless Telemetry Load And Displacement Sensor For Orthopaedic Applications, William Anderson

Electronic Thesis and Dissertation Repository

Due to sensor size and supporting circuitry, in vivo load and deformation measurements are currently restricted to applications within larger orthopaedic implants. The objective of this thesis is to repurpose a commercially available low-power, miniature, wireless, telemetric, tire-pressure sensor (FXTH87) to measure load and deformation for future use in biomechanical applications. The capacitive transducer membrane of the FXTH87 was modified, and a relationship was reported between applied compressive deformation and sensor signal value. The sensor package was embedded within a deformable enclosure to illustrate potential applications of the sensor for monitoring load. Finite element analysis was an effective tool to …

Influence Of Extracellular Matrix Stiffness And Topography On Neuronal Cell Behavior And Neurite Outgrowth, Mohan Yasodharababu

Graduate Theses and Dissertations

The focus of regeneration therapy for traumatic brain injuries and Alzheimer's disease is on the promotion and growth of neuronal cells. In vitro research attempts to improve this by modifying the stiffness and topography of the extracellular matrix (ECM). However, the limitations of in vitro experiments make it difficult to control the individual factors influencing neuronal cell growth. A computational model can be used to decouple individual factors and study them individually to gain a better understanding of the mechanics between the neuronal cell and ECM, which will aid in the design of in vitro experimental studies.

This study develops …

Interrelation Of Thermal Stimulation With Haptic Perception, Emotion, And Memory, Mehdi Hojatmadani

USF Tampa Graduate Theses and Dissertations

Haptics is an interdisciplinary field of science that deals with how humans perceive and respond to different sensory cues perceived through touch. Thermal haptics as a branch deals with how humans perceive the temperature sensation and respond to that. The process in which thermal perception occurs is well known to researchers. What seems missing in the literature is how temperature interacts or sometimes intervenes in other physiological and psychological aspects of our lives. In this research, a series of studies are presented where the main focus was how temperature and brain interact with each other to impede or enhance our …

Development Of A Pneumatically Controllable Microdroplet Generator With Electrical Sensing, Gnanesh Nagesh

Electronic Theses and Dissertations

Microfluidic droplet generation is popular in lab-on-a-chip based biochemical analysis because it can provide precise and high throughput fluids in the form of small droplets. This thesis presents a T-junction microdroplet generator with pneumatic actuation for regulating droplet size and a capacitance-based sensor with real-time sensing capability for characterizing droplet composition and size. The multi-layer device developed in this thesis is compatible with rapid manufacturing using a desktop-based laser cutter to fabricate the fluidic and pneumatic layers. A finite element based numerical model was developed to predict the best operating and geometric parameters for droplet generation. It was revealed that …

Design Of A Pneumatic Soft Robotic Actuator Using Model-Based Optimization, Mahsa Raeisinezhad

Theses and Dissertations

In this thesis, the design and optimization process of a novel soft intelligent modular pad (IntelliPad) for the purpose of pressure injury prevention is presented. The structure of the IntelliPad consists of multiple individual multi-chamber soft pneumatic-driven actuators that use pressurized air and vacuum. Each actuator is able to provide both vertical and horizontal motions that can be controlled independently. An analytical modeling approach using multiple cantilever beams and virtual springs connected in a closed formed structure was developed to analyze the mechanical performance of the actuator. The analytical approach was validated by a finite element analysis. For optimizing the …

Hand Strength And Dexterity Enhancer, Julia Ann Denison, Autumn B. Rexford, Melissa A. Kurani, Christina K. Fong

Biomedical Engineering

Good Grips created the hand strength and dexterity enhancer project to meet the challenge presented by Bill Phelps. He has Inclusion Body Myositis (IBM), an inflammatory muscle disease characterized by progressive muscle weakness and atrophy. Bill has limited strength in both hands and lost the ability to bend his fingers, making it difficult to grip anything. He needed a device that would help with everyday tasks such as writing, lifting, and holding various objects.

Our team consists of four engineering students attending Cal Poly, San Luis Obispo. We researched, designed, manufactured, and tested a device that would fulfill the problem …

Development Of A Wearable Haptic Feedback Device For Upper Limb Prosthetics Through Sensory Substitution, Marco B.S. Gallone

Electronic Thesis and Dissertation Repository

Haptics can enable a direct communication pipeline between the artificial limb and the brain; adding haptic sensory feedback for prosthesis wearers is believed to improve operation without drawing too much of the user's attention. Through neuroplasticity, the brain can become more cognizant of the information delivered through the skin and may eventually interpret it as inherently as other natural senses. In this thesis, a wearable haptic feedback device (WHFD) is developed to communicate prosthesis sensory information. A 14-week, 6-stage, between subjects study was created to investigate the learning trajectory as participants were stimulated with haptic patterns conveying joint proprioception. 37 …

Magnetic Gradient-Based Magnetic Tweezer System For 3d And Swarm Control Of Microswimmer, Xiao Zhang

Mechanical Engineering Research Theses and Dissertations

Microscale manipulation has very promising potential in medical applications such as drug delivery, minimal and invasion surgery. Contactless control is preferable as remote manipulation is necessary for in vivo applications. Among different control methods, magnetic power source is more suitable and robust for the applications mentioned above. Presented here is a magnetic tweezer system, which manipulates microscale magnetic particles using magnetic forces created by magnetic field gradient. The proposed system has three advantages: First, force applied by the magnetic tweezer system does not contact with the target object and can be generated in different directions. Second, the magnetic tweezer system …

Post-Traumatic Elbow Contracture Characterization And Physical Therapy-Based Treatment Strategies In A Preclinical Model, Alex Reiter

McKelvey School of Engineering Theses & Dissertations

The elbow is the most commonly dislocated joint in the pediatric population and second most common in adults. As one of the most congruous joints in the body, slight changes in biomechanics due to injury can lead to drastic reductions in range of motion causing potential quality of life issues. Post-traumatic joint contracture occurs in 12% of patients following elbow dislocation or fracture, and it is characterized by a loss in ROM, joint stiffness, and pain. Preventing joint contracture and functional deficits from occurring is one of the primary goals when managing these injuries. A rat model of joint contracture …

Gait Rehabilitation Using Biomechanics And Exoskeletons, Jacob Bloom

Electronic Theses and Dissertations

A healthy gait is often taken for granted when walking. However, if a stroke, spinal cord injury (SCI), or traumatic event occurs the ability to walk may be lost. In order to relearn how to walk, gait rehabilitation is required. Including arm swing in gait rehabilitation has been shown to help in this process. This thesis presents two tasks to investigate the mechanics of arm swing and ways to provide assistance to induce arm swing in gait rehabilitation.

The firsts task completed was a study on the effects of forearm movement during gait. Twelve healthy subjects walked under three conditions …

Motor Control-Based Assessment Of Therapy Effects In Individuals Post-Stroke: Implications For Prediction Of Response And Subject-Specific Modifications, Ashley Rice

Doctoral Dissertations

Producing a coordinated motion such as walking is, at its root, the result of healthy communication pathways between the central nervous system and the musculoskeletal system. The central nervous system produces an electrical signal responsible for the excitation of a muscle, and the musculoskeletal system contains the necessary equipment for producing a movement-driving force to achieve a desired motion. Motor control refers to the ability an individual has to produce a desired motion, and the complexity of motor control is a mathematical concept stemming from how the electrical signals from the central nervous system translate to muscle activations. Exercising a …

Design And Control Of A Peristaltic Pump To Simulate Left Atrial Pressure In A Conductive Silicone Model, Jeremy Collins

Mechanical Engineering Undergraduate Honors Theses

According to the CDC, atrial fibrillation is responsible for more than 454,000 hospitalizations and approximately 158,000 deaths per year. A common treatment for atrial fibrillation is catheter ablation, a process in which a long flexible tube is guided through the femoral artery and to the source of arrhythmia in the heart, where it measures the electrical potential at various locations and converts problematic heart tissue to scar tissue via ablation. This paper details the design and control of a low-cost ($400) peristaltic pump system using repetitive control to replicate blood pressure in the left atrium in a conductive silicone model …

Performance And Economics Of Solar Inverters And Module Level Power Electronics In A 1 Mw Photovoltaic System, Maxwell Criswell

Biological and Agricultural Engineering Undergraduate Honors Theses

Photovoltaic solar panels convert sunlight to electricity in the form of direct current; therefore, a necessary component of every photovoltaic system is an inverter to convert the electricity to usable alternating current. There are various commercially available inverter technologies manufactured today such as microinverters, string inverters, and central inverters, as well as module level power electronic devices such as DC optimizers that are capable of improving system performance in string and central inverter systems. This thesis compares the performance and economics of five different inverter and module level power electronic systems through model simulation using Helioscope software. The five alternatives …

Simulation Of Fracture Strength Improvements Of A Human Proximal Femur Using Finite Element Analysis., Waleed Ebraheem Alim

Electronic Theses and Dissertations

The most common hip fracture in the elderly occurs as a result of a fall to the side with impact over the greater trochanter resulting in a fracture of the proximal femur. The fracture usually involves the femoral neck or the intertrochanteric region. It has recently been determined that the fracture crack of a hip fracture typically initiates on the superior-lateral cortex of the femoral neck and then propagates across the femoral neck, resulting in a complete fracture. The strength of the superior-lateral cortex of the femoral neck is likely determined by the combined properties of the generally thin cortex …

Healthy Aging In Place: An Integrated Smart Home Using Alexa-Compatible Technology, Tyler Kryst

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this research was to address current healthcare concerns among the aging population. Around the globe, the average life expectancy is projected to continue increasing resulting in a higher prevalence of age-related disease. With the ever-increasing capabilities of modern technology, it is necessary to apply this technology to increase the health and safety of older adults. This work had three objectives. The first objective was the establishment of an integrated smart home aimed at creating a healthy aging-in-place environment through the use of Alexa. The second objective was the development and integration of a completely custom health device …

Patient-Specific Finite Element Analysis For Mandibular Fracture Fixation, Ethan Snyder

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis proposes an approach for Finite Element Analysis (FEA) of mandibular fracture fixation. Using a Computerized Tomography (CT) scan of mandible obtained from a specific person, the material characteristics, density and modulus of elasticity, were determined from a set of discrete points within the mandible that are 1mm spaced based on the Hounsfield Units of these points. The mandible geometry was sectioned to simulate a fracture. Muscle and mastication forces were added to replicate post-surgery loading. Using a standard linear miniplate, this material model was compared with two commonly used mandibular cortical shell bone models: isotropic and orthotropic. A …

A Generalized Method For Predictive Simulation-Based Lower Limb Prosthesis Design, Mark Price

Doctoral Dissertations

Lower limb prostheses are designed to replace the functions and form of the missing biological anatomy. These functions are hypothesized to improve user outcome measures which are negatively affected by receiving an amputation – such as metabolic cost of transport, preferred walking speed, and perceived discomfort during walking. However, the effect of these design functions on the targeted outcome measures is highly variable, suggesting that these relationships are not fully understood. Biomechanics simulation and modeling tools are increasingly capable of analyzing the effects of a design on the resulting user gait. In this work, prothesis-aided gait is optimized in simulation …

Drive Leg And Stride Leg Ground Reaction Forces Relationship To Medial Elbow Stress And Velocity In Collegiate Baseball Pitchers, Brett Smith

Biomedical Engineering Theses & Dissertations

This study examines several different kinetic variables in relation to pitch velocity and elbow varus torque in collegiate baseball pitchers using force plates, an inertial measurement unit, and a radar unit. The purpose of this study is to investigate the kinetic variables being measured and their relationship to pitch velocity and loads being placed on the medial elbow. Twelve collegiate baseball pitchers participated in this study, which was approved by the IRB. Impulse of the drive leg in the anterior-posterior direction, stride leg peak force in the anterior-posterior (AP) direction, elbow varus torque, and pitch velocity were all measured. Two …

Design And Biomechanical Evaluation Of A Clutch-Based Energy Storage And Release Assistive Knee Brace, Ericber Jimenez Francisco

Doctoral Dissertations

Knee osteoarthritis (OA) is a serious degenerative disease affecting over 240 million people around the world. The most disabling symptoms are joint pain, joint stiffness, and reduction in joint functionality. Medial compartment knee OA is the most common case of unicompartmental knee OA, and pain and progression have been associated with tibiofemoral alignment in early to moderate knee OA patients, mainly due to its association with knee loading as measured by knee adduction moment (KAM) and tibiofemoral contact forces (KCF). Valgization knee braces have been developed to correct the malalignment at the tibiofemoral joint, but they have no direct effect …

Rational Design Of Advanced Functional Materials For Electrochemical Devices, Shun Lu

Electronic Theses and Dissertations

In recent years, there has been a fast-growing trend in developing urea (CO(NH2)2) as a substitute H2 carrier in energy conversion due to its high energy density, nontoxicity, stability, and nonflammability. Urea, a byproduct in the metabolism of proteins and a frequent contaminant in wastewater, is an abundant compound that has demonstrated favorable characteristics as a hydrogen-rich fuel source with 6.7 wt % gravimetric hydrogen content. Also, there is 2-2.5 wt % urea from mammal urine; therefore, 0.5 million ton of additional fuels will be produced per year just from human urine (240 million ton each year). Electrochemical oxidation has …

Additive Manufacturing In Personalized Medicine: Patient-Customized Solid Dose Medicines, And Patient-Customized Wound Care Device, Amir Najarzadeh

Theses and Dissertations--Mechanical Engineering

Personalized Medicine - from a one-size fits all to a tailored approach is the future in pharmaceutical therapeutics and medical applications. The aim of this study is demonstrate additive manufacturing in two personalized medicine applications: 1. Patient- customized solid dose medicines, and 2. Patient-customized wound care device. The aim of the first application is to develop an inexpensive and accurate method to design and fabricate patient-customized tablets. Particularly this paper focuses on fabricating and dose controlling of patient-customized extended release prednisolone-poly(vinyle alcohole) PVA. Dry-Blending, Wet Granulation, Extrusion, Spherionization, Hot melt extrusion (HME) was adopted to produce drug loaded prednisolone-PVA filaments …

Tibial Strains And Tray-Bone Micromotions After Total Knee Arthroplasty: Computational Studies Evaluating The Tibial Fixation, Huizhou Yang

Electronic Theses and Dissertations

Cemented and cementless fixation in total knee arthroplasty (TKA) have been successfully used for decades. As the number of younger and more active patients treated with TKA continues to increase, long-term implant survivorship is of increasing importance. One of the most common complications and hence the reason for revision is mechanical loosening (23.1% of all revised TKA). The loosening mechanisms have been proposed for different fixation types. For cemented fixation, bone remodeling after surgery is regulated by the changes in strain energy density (SED). The recruitment of osteoclasts and osteoblasts is controlled by SED-related signals. Insufficient stimuli can promote bone …