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Full-Text Articles in Biomedical Engineering and Bioengineering
Kinematic Analysis Of Spinal Cord Injury Animals Treated With A Neurotrophin-Infused Scaffold And Body Weight Supported Treadmill Training, Alexander Herman
Kinematic Analysis Of Spinal Cord Injury Animals Treated With A Neurotrophin-Infused Scaffold And Body Weight Supported Treadmill Training, Alexander Herman
Theses and Dissertations
Spinal Cord Injury (SCI) is a condition that affects around 250,000 Americans with no cure. Existing treatments rely on physical therapies such as body weight support treadmill training (BWSTT). Treatments currently being researched include the use of implantable cells and biomaterials. Our study investigated the changes in locomotive gait and range of motion via a combinational treatment using a bioengineered scaffold [poly (N-isopropyl acrylamide) polyethylene glycol (PNIPAAm-g-PEG) with BDNF and NT-3] and rehabilitation training using BWSTT in a clinically relevant contusion SCI animal model. Five different groups of animals (Sham, Injury, BWSTT, Implant, and Combinational) were tested on a treadmill …