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Full-Text Articles in Biomedical Engineering and Bioengineering
A Meshless Approach To Computational Pharmacokinetics, Anthony Matthew Khoury
A Meshless Approach To Computational Pharmacokinetics, Anthony Matthew Khoury
Doctoral Dissertations and Master's Theses
The meshless method is an incredibly powerful technique for solving a variety of problems with unparalleled accuracy and efficiency. The pharmacokinetic problem of transdermal drug delivery (TDDD) is one such topic and is of significant complexity. The locally collocated meshless method (LCMM) is developed in solution to this topic. First, the meshless method is formulated to model this transport phenomenon and is then validated against an analytical solution of a pharmacokinetic problem set, to demonstrate this accuracy and efficiency. The analytical solution provides a locus by which convergence behavior are evaluated, demonstrating the super convergence of the locally collocated meshless …
A Novel Resistance Exercise Machine For Use In A Lower Body Negative Pressure Box To Counteract The Effects Of Weightlessness, Christine M. Dailey
A Novel Resistance Exercise Machine For Use In A Lower Body Negative Pressure Box To Counteract The Effects Of Weightlessness, Christine M. Dailey
Doctoral Dissertations and Master's Theses
Physiological deconditioning is a critical problem in space, especially during long-term missions. Resistance exercise coupled with lower body negative pressure (LBNP) has been shown to be effective in counteracting some of the deconditioning related problems. This thesis describes the development of a compact and effective resistance exercise machine that works within an existing environmentally controlled LBNP Box and is designed to simulate both exercise and sitting, to prevent microgravity-induced deconditioning by simulating physiological and biomechanical features of upright exercise and daily activities. Theoretical calculations are carried out to determine whether kinematics, musculoskeletal loadings, and metabolic rate during supine exercise within …