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Understanding The Role Of Colloidal Particles In Electroporation Mediated Delivery, Alisha Peterson
Understanding The Role Of Colloidal Particles In Electroporation Mediated Delivery, Alisha Peterson
USF Tampa Graduate Theses and Dissertations
Electroporation (EP) is a physical non-viral technique used to deliver therapeutic molecules across the cell membrane. During electroporation an external electric field is applied across a cell membrane and it causes pores to form. These pores then allow the surrounding media containing the therapeutics to diffuse across the membrane. This technique has been specifically studied as a promising gene and drug delivery system. Colloidal particles have also proven to be promising for a variety of biological applications including molecular delivery, imaging, and tumor ablation, due to their large surface area and tunable properties. In more recent years researchers have explored …