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Biomedical Engineering and Bioengineering Commons™
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- Keyword
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- 25-dihydroxyvitamin D3 (1)
- Angiogenesis (1)
- CD117+ endothelial cells (1)
- Computational model (1)
- Energy Expenditure (1)
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- Estrogen receptors; breast cancer; vitamin D metabolites; 24R (1)
- Extracellular Matrix Stiffness (1)
- Extracellular matrix (1)
- Geared Manual Wheelchair (1)
- Glenohumeral Joint Dynamics (1)
- KRAS (1)
- Mechano-receptors (1)
- Mechanotransduction (1)
- Non-Small Cell Lung Cancer (1)
- Primary Cilia (1)
- Pulmonary hypertension (1)
- Receptor Tyrosine Kinase (1)
- Shoulder Biomechanics (1)
- Spinal Cord Injury (1)
- Wheelchair Biomechanics (1)
Articles 1 - 4 of 4
Full-Text Articles in Biomedical Engineering and Bioengineering
Quantitative Evaluation Of Geared Manual Wheelchair Mobility In Individuals With Spinal Cord Injury: An Integrative Approach, Omid Jahanian
Quantitative Evaluation Of Geared Manual Wheelchair Mobility In Individuals With Spinal Cord Injury: An Integrative Approach, Omid Jahanian
Theses and Dissertations
The purpose of this dissertation is to quantify the effects of using geared wheelchair wheels on upper extremity biomechanics and energy expenditure during functional mobility tasks in individuals with spinal cord injury (SCI). The effects of using geared wheels on hand-rim biomechanics, glenohumeral joint dynamics, and shoulder muscle activity were investigated during manual wheelchair propulsion over tiled and carpeted level-floors and up a ramp in low gear (1.5:1) and standard gear (1:1) conditions. The results for the hand-rim biomechanics indicated that regardless of the terrain, using the geared wheels in the low gear condition significantly decreased the propulsion speed, stroke …
The Role Of Kras In Mechanosensing In Non-Small Cell Lung Cancer, Krista M. Powell
The Role Of Kras In Mechanosensing In Non-Small Cell Lung Cancer, Krista M. Powell
Theses and Dissertations
Lung cancer is the number one cause of cancer related death worldwide, with more than 1.6 million fatalities each year. Non-small cell lung cancer (NSCLC) accounts for 80-85% of all lung cancers, with KRAS being one of the most prevalent oncogenic driver mutations. Therapeutic approaches for KRAS-mutated NSCLC have been extensively explored due to the US National Cancer Institute RAS Initiative, but methods of directly targeting KRAS or downstream effectors, such as MEK, still have poor results. Previous reports have shown that KRAS-mutated NSCLC activate distinct receptor tyrosine kinases (RTKs) depending on the epithelial or mesenchymal state. Epithelial-to-mesenchymal transition (EMT) …
The Role Of The Mechanical Environment On Cd117+ Endothelial Cell Angiogenesis, Patrick Link
The Role Of The Mechanical Environment On Cd117+ Endothelial Cell Angiogenesis, Patrick Link
Theses and Dissertations
Angiogenesis is a complex process coordinating cell migration, proliferation, and lumen formation. Changes to the microenvironment regulate angiogenesis through mechanotransduction and cytokine signals. In pulmonary hypertension, something in the process becomes abnormal, resulting in changes to the microenvironment and the formation of a glomerulus of dysfunctional capillaries, called a plexiform lesion. Endothelial cells, expressing CD117 (CD117+ EC clones) increase in the plexiform lesions of pulmonary hypertension, independent of pro-angiogenic VEGF signaling. We hypothesize that the mechanical environment and the macromolecular composition of the extracellular matrix, both, contribute to the aberrant angiogenesis. When we changed the mechanical environment, we changed the …
Eralpha Isoforms Modulate The Tumorigenicity Of 24r,25(Oh)2d3 In Estrogen-Responsive Cancer, Anjali Verma
Eralpha Isoforms Modulate The Tumorigenicity Of 24r,25(Oh)2d3 In Estrogen-Responsive Cancer, Anjali Verma
Theses and Dissertations
Over 200,000 cases of breast cancer are diagnosed every year. Nearly 20% of these patients supplement their diets with some form of vitamin D. This high frequency of vitamin D supplement use may be due in part to research suggesting that cancer patients with higher serum vitamin D3 levels have better prognoses than patients with low serum vitamin D3. However, double-blind clinical trials on the efficacy of vitamin D3 supplementation in breast cancer have been inconclusive. A recent meta-analysis showed evidence of reduced cancer recurrence in patients taking vitamin D3 supplements who had ‘estrogen receptor positive’ …