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Biomedical Engineering and Bioengineering Commons™
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- EEG (2)
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Articles 1 - 8 of 8
Full-Text Articles in Biomedical Engineering and Bioengineering
Nanosecond Pulsed Electric Field Modulates Electron Transport And Mitochondrial Structure And Function, Lucas Nelson Potter
Nanosecond Pulsed Electric Field Modulates Electron Transport And Mitochondrial Structure And Function, Lucas Nelson Potter
Biomedical Engineering Theses & Dissertations
Pulsed power treatment has been used to induce regulated cell death (RCD) in cells or ablate tumors in animals. A subset of pulsed power as electroporation with high voltage and pulse duration of milliseconds is used for biomedical treatment to induce pores in the plasma membrane of cells. Nanosecond Pulsed Electric Fields (nsPEFs)– an extension of electroporation, uses waveforms with pulse durations on the order of 10-900 nanoseconds. nsPEF treatment has demonstrated intracellular effects for potential biomedical applications. In this work, nsPEF treatment is used to demonstrate changes that affect viability, plasma membrane permeability ROS (Reactive Oxygen Species) in the …
Engineering Of Ideal Systems For The Study And Direction Of Stem Cell Asymmetrical Division And Fate Determination, Martina Zamponi
Engineering Of Ideal Systems For The Study And Direction Of Stem Cell Asymmetrical Division And Fate Determination, Martina Zamponi
Biomedical Engineering Theses & Dissertations
The cellular microenvironment varies significantly across tissues, and it is constituted by both resident cells and the macromolecules they are exposed to. Cues that the cells receive from the microenvironment, as well as the signaling transmitted to it, affect their physiology and behavior. This notion is valid in the context of stem cells, which are susceptible to biochemical and biomechanical signaling exchanged with the microenvironment, and which plays a fundamental role in establishing fate determination and cell differentiation events. The definition of the molecular mechanisms that drive stem cell asymmetrical division, and how these are modulated by microenvironmental signaling, is …
Do Different Pathologies Affect The Relationship Between The Stiffness Of The Plantar Fascia And The Function Of The Mtp Joint?, Madeline Ryan Pauley
Do Different Pathologies Affect The Relationship Between The Stiffness Of The Plantar Fascia And The Function Of The Mtp Joint?, Madeline Ryan Pauley
Biomedical Engineering Theses & Dissertations
Compared to healthy individuals, individuals with plantar fasciitis and diabetes experience material and structural property changes to soft tissues in the feet. The purpose of this study was to compare the relationship between material properties, power absorption, and energy storage characteristics to metatarsal power between healthy, plantar fasciitis symptomatic and asymptomatic, and diabetic participants. Investigating material change differences as well as energy storage and transfer trends in different pathology groups can lead to a better overall understanding of power transfer at the metatarsophalangeal joint (MTP). Participants were recruited for kinematic gait analysis and lower extremity shear wave elastography analysis and …
Validation Of Nanosecond Pulse Cancellation Using A Quadrupole Exposure System, Hollie A. Ryan
Validation Of Nanosecond Pulse Cancellation Using A Quadrupole Exposure System, Hollie A. Ryan
Biomedical Engineering Theses & Dissertations
Nanosecond pulsed electric fields (nsPEFs) offer a plethora of opportunities for developing integrative technologies as complements or alternatives to traditional medicine. Studies on the biological effects of nsPEFs in vitro and in vivo have revealed unique characteristics that suggest the potential for minimized risk of complications in patients, such as the ability of unipolar nsEPs to create permanent or transient pores in cell membranes that trigger localized lethal or non-lethal outcomes without consequential heating. A more recent finding was that such responses could be diminished by applying a bipolar pulse instead, a phenomenon dubbed bipolar cancellation, paving the way …
Flexible Electrochemical Lactate Sensor, Peyton Miesse
Flexible Electrochemical Lactate Sensor, Peyton Miesse
Biomedical Engineering Theses & Dissertations
Lactic acid is a vital indicator for shock, trauma, stress, and exercise intolerance. It is a key biomarker for increases in stress levels and is the primary metabolically produced acid responsible for tissue acidosis that can lead to muscle fatigue and weakness. During intensive exercise, the muscles go through anerobic metabolism to produce energy. This leads to decreases in the blood flow of nutrients and oxygen to the muscles and increases in lactate production, which in turn cause lactic acidosis. Currently, changes in blood lactate concentrations are monitored by sensors that can be invasive via blood or wearable based sensors …
Impedance Analysis Of Tissues In Nspef Treatment For Cancer Therapy, Edwin Ayobami Oshin
Impedance Analysis Of Tissues In Nspef Treatment For Cancer Therapy, Edwin Ayobami Oshin
Biomedical Engineering Theses & Dissertations
Nanosecond pulsed electric field (nsPEF) for cancer therapy is characterized by applications of high voltage pulses with low pulsed energy to induce non-thermal effects on tissues such as tumor ablation. It nonthermally treats tissues via electroporation. Electroporation is the increase in permeabilization of a cell membrane due to the application of high pulsed electric field. The objective of this study was to investigate the effect of nsPEF on tissue by monitoring the tissue’s impedance in real-time. Potato slices (both untreated and electroporated), and tumors extracted from female BALBc mice were studied. 100ns, 1-10kV pulses were applied to the tissues using …
Development Of A Practical Visual-Evoked Potential-Based Brain-Computer Interface, Nicholas R. Waytowich
Development Of A Practical Visual-Evoked Potential-Based Brain-Computer Interface, Nicholas R. Waytowich
Biomedical Engineering Theses & Dissertations
There are many different neuromuscular disorders that disrupt the normal communication pathways between the brain and the rest of the body. These diseases often leave patients in a `locked-in" state, rendering them unable to communicate with their environment despite having cognitively normal brain function. Brain-computer interfaces (BCIs) are augmentative communication devices that establish a direct link between the brain and a computer. Visual evoked potential (VEP)- based BCIs, which are dependent upon the use of salient visual stimuli, are amongst the fastest BCIs available and provide the highest communication rates compared to other BCI modalities. However. the majority of research …
Multichannel Characterization Of Brain Activity In Neurological Impairments, Yalda Shahriari
Multichannel Characterization Of Brain Activity In Neurological Impairments, Yalda Shahriari
Biomedical Engineering Theses & Dissertations
Hundreds of millions of people worldwide suffer from various neurological and psychiatric disorders. A better understanding of the underlying neurophysiology and mechanisms for these disorders can lead to improved diagnostic techniques and treatments. The objective of this dissertation is to create a novel characterization of multichannel EEG activity for selected neurological and psychiatric disorders based on available datasets. Specifically, this work provides spatial, spectral, and temporal characterizations of brain activity differences between patients/animal models and healthy controls, with focus on modern techniques that quantify cortical connectivity, which is widely believed to be abnormal in such disorders. Exploring the functional brain …