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Full-Text Articles in Biomedical Engineering and Bioengineering
Tibial Compression During Activities Of Daily Living In Young And Older Adults, Elijah Miles Walker
Tibial Compression During Activities Of Daily Living In Young And Older Adults, Elijah Miles Walker
Boise State University Theses and Dissertations
Introduction: Stress fracture, particularly in the tibia, is a growing concern among older adults (greater than 65 years). Older adults may have inherent stress fracture risk from ageing-related changes to their musculoskeletal system. Specifically, older adults reduced ankle neuromuscular function may impair their ability to attenuate repetitive compressive forces experienced during daily locomotor tasks and increase the likelihood of suffering bone damage from decreased bone tissue elasticity. Yet, it is currently unknown if older adults exhibit greater tibial compression than their younger counterparts during locomotor tasks. Purpose: This study sought to quantify tibial compression for older and younger adults when …
Role Of The Nuclear Envelope In The Mechanoregulation Adipogenesis, Matthew H. Goelzer
Role Of The Nuclear Envelope In The Mechanoregulation Adipogenesis, Matthew H. Goelzer
Boise State University Theses and Dissertations
Mechanical signals are known regulators of mesenchymal stem cell (MSC) fate, regulating their differentiation into osteoblasts, chondrocytes, and adipocytes. These relevant mechanical signals reach to nucleus through nuclear envelope proteins such as Lamin A/C and the Linker of the Nucleoskeleton and Cytoskeleton (LINC) complexes. Within the context of bone, clinically relevant mutations of Lamin A/C and the LINC complexes have been shown to alter adipogenic and osteogenic MSC differentiation patterns, suggesting that that nucleo-cytoskeletal connectivity provided by nuclear envelope is important in regulating MSC fate. Using MSC adipogenesis as a model of MSC mechanical regulation, the goal of this work …