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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 2 of 2
Full-Text Articles in Biomedical Engineering and Bioengineering
Rapid Self-Assembly Of Polymer Nanoparticles For Synergistic Codelivery Of Paclitaxel And Lapatinib Via Flash Nanoprecipitation, Shani L. Levit, Hu Yang, Christina Tang
Rapid Self-Assembly Of Polymer Nanoparticles For Synergistic Codelivery Of Paclitaxel And Lapatinib Via Flash Nanoprecipitation, Shani L. Levit, Hu Yang, Christina Tang
Chemical and Biochemical Engineering Faculty Research & Creative Works
Taxol, a formulation of paclitaxel (PTX), is one of the most widely used anticancer drugs, particularly for treating recurring ovarian carcinomas following surgery. Clinically, PTX is used in combination with other drugs such as lapatinib (LAP) to increase treatment efficacy. Delivering drug combinations with nanoparticles has the potential to improve chemotherapy outcomes. In this study, we use Flash NanoPrecipitation, a rapid, scalable process to encapsulate weakly hydrophobic drugs (logP < 6) PTX and LAP into polymer nanoparticles with a coordination complex of tannic acid and iron formed during the mixing process. We determine the formulation parameters required to achieve uniform nanoparticles and evaluate the drug release in vitro. The size of the resulting nanoparticles was stable at pH 7.4, facilitating sustained drug release via first-order Fickian diffusion. Encapsulating either PTX or LAP into nanoparticles increases drug potency (as indicated by the decrease in IC-50 concentration); we observe a 1500-fold increase in PTX potency and a six-fold increase in LAP potency. When PTX and LAP are co-loaded in the same nanoparticle, they have a synergistic effect that is greater than treating with two single-drug-loaded nanoparticles as the combination index is 0.23 compared to 0.40, respectively.
Encapsulation And Extended Release Of Anti-Cancer Anastrozole By Stealth Nanoparticles, Kumkum Sarkar, Hu Yang
Encapsulation And Extended Release Of Anti-Cancer Anastrozole By Stealth Nanoparticles, Kumkum Sarkar, Hu Yang
Chemical and Biochemical Engineering Faculty Research & Creative Works
To improve delivery efficiency of anastrozole, we applied dendrimer-based stealth nanoparticles to encapsulate anastrozole to formulate stealth anastrozole nanoparticles. This work demonstrated that stealth nanoparticles composed of a PAMAM dendrimers core and a PEG layer could encapsulate anastrozole, hence causing improved water solubility of anastrozole. Anastrozole encapsulation depended on concentration of stealth nanoparticles and generation of dendrimer. The extended release of anastrozole was achieved. We envisioned that this highly structurally adaptable stealth nanoparticle could be further biofunctionalized to construct a targeted therapeutic delivery system for breast cancer treatment.