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Full-Text Articles in Biomedical Engineering and Bioengineering
Erythrocyte Deformability In Response To Glucose Using Liquid Crystals, Jayden Goff
Erythrocyte Deformability In Response To Glucose Using Liquid Crystals, Jayden Goff
Biomedical Engineering Undergraduate Honors Theses
The worldwide prevalence of diabetes mellitus is rapidly increasing with about 9.3% of the adult population living with the disease. People with diabetes have trouble regulating their blood glucose levels which typically leads to hyperglycemia. Under normal physiological conditions, erythrocytes can undergo deformations in response to shear stress when passing through capillaries with a smaller diameter. Poorly managed hyperglycemia can lead to the glycosylation of erythrocyte membrane proteins and hemoglobin. This glycosylation leads to increased rigidity of the cells along with decreased deformability in response to mechanical stress; therefore, these cells have a higher susceptibility of getting stuck in the …
Characterization Of Oxone Mediated Tempo-Oxidized Nano Cellulose Mixed-Matrix Membranes During Ultrafiltration And Hemodialysis, Kristyn Robling
Characterization Of Oxone Mediated Tempo-Oxidized Nano Cellulose Mixed-Matrix Membranes During Ultrafiltration And Hemodialysis, Kristyn Robling
Biomedical Engineering Undergraduate Honors Theses
The ninth leading cause of death in the United States is kidney disease, and hemodialysis is the process most commonly prescribed for treatment. It utilizes a selectively permeable membrane filter to remove toxins such as urea from the blood and retain necessary protein levels. However, traditional filters, such as cellulose triacetate, used during dialysis can be inefficient in terms of separation performance and reduction of fouling. Recent exploration of nanoparticles has resulted in the creation of Oxone Mediated TEMPO-Oxidized Nano Cellulose which has properties that are believed to increase hydrophilicity, increase tensile capacity, decrease membrane resistance and lower fouling, making …
Analysis Of Blood Purification Studies On Oxone Mediated Tempo-Oxidized Nano Cellulose Mixed-Matrix Membranes, Tony Roller
Analysis Of Blood Purification Studies On Oxone Mediated Tempo-Oxidized Nano Cellulose Mixed-Matrix Membranes, Tony Roller
Biomedical Engineering Undergraduate Honors Theses
End-stage renal disease (ESRD) is currently the ninth leading cause of death in the United States, and of the 661,00 Americans diagnosed with ESRD, approximately 468,800 were on hemodialysis in 2016. Hemodialysis refers to a technique where a machine combined with a membrane, often referred to as an artificial kidney, is used to clean blood by removing any waste such as urea, potassium, and other smaller waste products while preserving the concentrations and integrity of cells and proteins in the blood. It has been shown in artificial blood studies that cellulose nanomaterials, like TEMPO/Oxidized cellulose nanoparticles (TOCNs), can be integrated …
Electrodialysis Device For In Vivo Power Delivery, Jessica L. Orton
Electrodialysis Device For In Vivo Power Delivery, Jessica L. Orton
Biomedical Engineering Undergraduate Honors Theses
It is estimated that over 3 million cardiac pacemakers have been implanted in patients globally. Current lithium-iodine pacemaker batteries last an average of about 10 years before the entire pacemaker unit must surgically be replaced, increasing the patient’s risk of procedure-related complications. Therefore, it is necessary to investigate means by which to extend the pacemaker battery lifetime. The renal vein and renal artery in the body naturally produce a salinity gradient through the filtering work of the kidneys. This salinity gradient energy potential can be harnessed through reverse electrodialysis (RED). RED is an electrochemical process that harnesses the Gibbs Free …
Antibacterial Properties Of A Cationic Imidazolium-Containing Poly(Ionic Liquid), Kaitlyn P. Brickey
Antibacterial Properties Of A Cationic Imidazolium-Containing Poly(Ionic Liquid), Kaitlyn P. Brickey
Biomedical Engineering Undergraduate Honors Theses
Poly(ionic liquids), or PILs, have been shown to have a number of biological applications as ligands, drug delivery vehicles, and nonviral DNA delivery mechanisms. Additionally, PILs have been proven to be efficient antibacterials. Imidazolium-containing PILs have promising results in antibacterial studies, but relating to their chain and charge density, only the effects of mono- & bis-imidazolium PILs have been sufficiently described in literature. The work detailed in this thesis aimed to further existing research on the effect of chain density by controlling the UV-initiator immobilization time. The effects of chain density were investigated by grafting poly(vinylimidazolium chloride) onto SiO2 …
Micellular Electrokinetic Chromatography For Studying Amyloid Beta Oligomer Membrane Affinity, Andrew Bryson
Micellular Electrokinetic Chromatography For Studying Amyloid Beta Oligomer Membrane Affinity, Andrew Bryson
Biomedical Engineering Undergraduate Honors Theses
Amyloid Beta (Aβ) was the major focus of this study. It is a peptide that is present in the brain with a high tendency to self-aggregate. When this protein aggregates, it forms oligomers and protofibrils which in turn are deposited as senile plaques in the brain. The reason for the concern with these plaques is their association with the neurological disorder Alzheimer’s disease. It has been found that the most dangerous oligomers are formed in a portion of the plasma membrane known as lipid rafts. The purpose of this study was to understand how micelles affect the aggregation properties of …
Local Delivery Of Ctla-4 Blockade Inhibits Growth Of Pancreatic Tumors, Jack Baltz
Local Delivery Of Ctla-4 Blockade Inhibits Growth Of Pancreatic Tumors, Jack Baltz
Biomedical Engineering Undergraduate Honors Theses
Immune checkpoint blockade has demonstrated great potential in activating antitumor immunity. Ipilimumab is a monoclonal antibody which targets cytotoxic T-lymphocyte antigen-4. CTLA-4 belongs to the CD28 class of receptors and is found on the surface of CD4+ and CD8+ T cells. CTLA-4 acts to suppress the immune system when bound to CD80 and CD86 receptors on antigen presenting cells. Ipilimumab, or anti-CTLA-4, has shown to be effective in significantly extending the survival of patients with metastatic melanoma. However, systemic delivery of Ipilimumab also induces significant side effects such as: colitis, dermatitis, uveitis, and hypophysitis. In order to minimize …