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Full-Text Articles in Biomedical Engineering and Bioengineering
Development Of In-Vitro And In-Vivo Devices To Study The Mechanobiology Of Ligament Healing, John Bayard Everingham
Development Of In-Vitro And In-Vivo Devices To Study The Mechanobiology Of Ligament Healing, John Bayard Everingham
Boise State University Theses and Dissertations
Ligament injuries are the most common sports injury in the United States. The current clinical practice for treating ligament injuries leaves many patients with significant pain and joint laxity for years following the initial injury. Controlled mechanical stimulation of the tissue after injury is necessary for robust healing, but the optimal mechanical environment for ligament healing is not fully understood. Alternative therapies, such as instrument assisted soft tissue mobilization (IASTM), offer a form of mechanical stimulation that is non-invasive and has shown promising clinical outcomes but the optimal dosage for IASTM treatments is unknown. The objective of this study was …
Real-Time Membrane Puncture Detection Using Force Sensors For Micro-Injections In Phantoms, Szymon Kowal
Real-Time Membrane Puncture Detection Using Force Sensors For Micro-Injections In Phantoms, Szymon Kowal
Electronic Thesis and Dissertation Repository
Micro-manipulators provide tools for researchers to improve workflow in common preclinical and clinical applications. Following drug delivery injections where drugs did not reach their target will squander research time, experimental animals and other resources. An ultrasound-guided robot developed at Robarts Research Institute was revised to implement closed-loop force feedback to compensate for tissue deformation during micro-interventions. Force sensors can detect puncture events as the needle penetrates tissue membranes, thereby reducing damage to surrounding tissues by preventing the needle from overshooting its target. Changing the angle of injection determined that the range of detectable forces during injections into tissue-mimicking phantoms suggests …