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Full-Text Articles in Biomedical Engineering and Bioengineering

Noninvasive Assessment Of Photoreceptor Structure And Function In The Human Retina, Robert Francis Cooper Oct 2015

Noninvasive Assessment Of Photoreceptor Structure And Function In The Human Retina, Robert Francis Cooper

Dissertations (1934 -)

The human photoreceptor mosaic underlies the first steps of vision; thus, even subtle defects in the mosaic can result in severe vision loss. The retina can be examined directly using clinical tools; however these devices lack the resolution necessary to visualize the photoreceptor mosaic. The primary limiting factor of these devices is the optical aberrations of the human eye. These aberrations are surmountable with the incorporation of adaptive optics (AO) to ophthalmoscopes, enabling imaging of the photoreceptor mosaic with cellular resolution. Despite the potential of AO imaging, much work remains before this technology can be translated to the clinic. Metrics …


Computational Approaches For Remote Monitoring Of Symptoms And Activities, Ferdaus Kawsar Oct 2015

Computational Approaches For Remote Monitoring Of Symptoms And Activities, Ferdaus Kawsar

Dissertations (1934 -)

We now have a unique phenomenon where significant computational power, storage, connectivity, and built-in sensors are carried by many people willingly as part of their life style; two billion people now use smart phones. Unique and innovative solutions using smart phones are motivated by rising health care cost in both the developed and developing worlds. In this work, development of a methodology for building a remote symptom monitoring system for rural people in developing countries has been explored. Design, development, deployment, and evaluation of e-ESAS is described. The system’s performance was studied by analyzing feedback from users. A smart phone …


Biomechanical Characerization And Evaluation Of Conservative Clubfoot Correction, Tamara Loren Cohen Oct 2015

Biomechanical Characerization And Evaluation Of Conservative Clubfoot Correction, Tamara Loren Cohen

Dissertations (1934 -)

Congential talipes equinovarus, or clubfoot, affects approximately 200,000 newborns worldwide each year and presents with equinovarus of the hindfoot, as well as cavus and adduction of the midfoot. In addition to bone malformation and displacement, soft tissue contractures encapsulate the medial and posterior aspects of the affected foot. The Ponseti method is a conservative treatment that progressively repositions the clubfoot through weekly casting, followed by bracing. Concerns exist regarding the variability in outcomes, resistance to treatment, and risk of relapse, which occur in approximately 10% of the population. Potential factors contributing to variability and resistant clubfoot include cast material performance, …


Biplanar Fluoroscopic Analysis Of In Vivo Hindfoot Kinematics During Ambulation, Janelle Ann Cross Jul 2015

Biplanar Fluoroscopic Analysis Of In Vivo Hindfoot Kinematics During Ambulation, Janelle Ann Cross

Dissertations (1934 -)

The overall goal of this project was to develop and validate a biplanar fluoroscopic system and integrated software to assess hindfoot kinematics. Understanding the motion of the foot and ankle joints may lead to improved treatment methods in persons with foot and ankle pathologies. During gait analysis, skin markers are placed on the lower extremities, which are defined as four rigid-body segments with three joints representing the hip, knee and ankle. This method introduces gross assumptions on the foot and severely limits the analysis of in depth foot mechanics. Multi-segmental models have been developed, but are susceptible to skin motion …