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Full-Text Articles in Biomedical Engineering and Bioengineering

Full-Field Vibrometry By High-Speed Digital Holography For Middle-Ear Mechanics, Ivo Dobrev Aug 2014

Full-Field Vibrometry By High-Speed Digital Holography For Middle-Ear Mechanics, Ivo Dobrev

Ivo Dobrev

Hearing loss affects approximately 1 in 10 people in the world and this percentage is increasing every year. Some of the most common courses for hearing loss are disorders of the human tympanic membrane (TM or eardrum) and middle-ear. Early detection and diagnosis of hearing loss as well as research and understanding of the hearing process depend on medical and research tools for quantification of the hearing capabilities, including the function of the human TM in the complex acoustic-mechanical transformation of environmental sounds into vibrations of the middle- and the inner-ear. Current ear exams are assessing the state of the …


Vicon Motion System, Arezoo Eshraghi Mar 2014

Vicon Motion System, Arezoo Eshraghi

AREZOO ESHRAGHI

No abstract provided.


Sparse Signal Reconstruction From Polychromatic X-Ray Ct Measurements Via Mass Attenuation Discretization, Renliang Gu, Aleksandar Dogandžić Jan 2014

Sparse Signal Reconstruction From Polychromatic X-Ray Ct Measurements Via Mass Attenuation Discretization, Renliang Gu, Aleksandar Dogandžić

Aleksandar Dogandžić

We propose a method for reconstructing sparse images from polychromatic x-ray computed tomography (ct) measurements via mass attenuation coefficient discretization. The material of the inspected object and the incident spectrum are assumed to be unknown. We rewrite the Lambert-Beer’s law in terms of integral expressions of mass attenuation and discretize the resulting integrals. We then present a penalized constrained least-squares optimization approach forreconstructing the underlying object from log-domain measurements, where an active set approach is employed to estimate incident energy density parameters and the nonnegativity and sparsity of the image density map are imposed using negative-energy and smooth ℓ1-norm penalty …


Xena: An Automated 'Open-Source' 129xe Hyperpolarizer For Clinical Use, Panayiotis Nikolaou, Aaron M. Coffey, Laura L. Walkup, Brogan M. Gust, Nicholas Whiting, Hayley Newton, Iga Muradyan, Mikayel Dabaghyan, Kaili Ranta, Gregory D. Moroz, Matthew S. Rosen, Samuel Patz, Michael J. Barlow, Eduard Y. Chekmenev, Boyd M. Goodson Dec 2013

Xena: An Automated 'Open-Source' 129xe Hyperpolarizer For Clinical Use, Panayiotis Nikolaou, Aaron M. Coffey, Laura L. Walkup, Brogan M. Gust, Nicholas Whiting, Hayley Newton, Iga Muradyan, Mikayel Dabaghyan, Kaili Ranta, Gregory D. Moroz, Matthew S. Rosen, Samuel Patz, Michael J. Barlow, Eduard Y. Chekmenev, Boyd M. Goodson

Nicholas Whiting

Here we provide a full report on the construction, components, and capabilities of our consortium’s “opensource”
large-scale (~1 L/h) 129Xe hyperpolarizer for clinical, pre-clinical, and materials NMR/MRI (Nikolaou et al., Proc. Natl. Acad. Sci. USA, 110, 14150 (2013)). The ‘hyperpolarizer’ is automated and built mostly of off-the-shelf components; moreover, it is designed to be cost-effective and installed in both research laboratories and clinical settings with materials costing less than $125,000. The device runs in the xenon-rich regime (up to 1800 Torr Xe in 0.5 L) in either stopped-flow or single-batch mode—making cryo-collection of the hyperpolarized gas unnecessary for many applications. …