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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 6 of 6
Full-Text Articles in Biomedical Engineering and Bioengineering
Single-Cell Impedance Spectroscopy, David Paul Lange
Single-Cell Impedance Spectroscopy, David Paul Lange
Master's Theses
Impedance spectroscopy (IS) is an important tool for cell detection and characterization in medical and food safety applications. In this thesis, the Cal Poly Biofluidics Lab’s impedance spectroscopy system was re-evaluated and optimized for single-cell impedance spectroscopy. To evaluate the IS system, an impedance spectroscopy bioMEMS chip was fabricated in the Cal Poly Microfabcrication lab, software was developed to run IS experiments, and studies were run to validate the system. To explore IS optimization, Maxwell’s mixture theorem and the Schwartz-Christoffel transform were used to calculate an analytic impedance solution to the co-planar electrode system,a novel volume fraction to account for …
Transmission Probability Of Embolic Debris Through The Aortic Arch And Daughter Vessels During A Transcatheter Aortic Valve Replacement Procedure, Jessica Lena Wirth
Transmission Probability Of Embolic Debris Through The Aortic Arch And Daughter Vessels During A Transcatheter Aortic Valve Replacement Procedure, Jessica Lena Wirth
Master's Theses
Cerebral ischemia leading to an ischemic stroke is a possible complication of a transcatheter aortic valve replacement (TAVR) procedure. This is because embolic debris can become dislodged and travel through the aortic arch, where they either continue to the descending aorta and join the systemic circulation or travel into the cerebral vasculature through the three daughter vessels that branch off the top of the aortic arch. These three vessels are the brachiocephalic artery, the left subclavian artery, and the left common carotid artery. These three vessels lead either directly or indirectly to the cerebral vasculature, where the diameter of vessels …
A 3-Dimensional In Silico Test Bed For Radiofrequency Ablation Catheter Design Evaluation And Optimization, Carolyn Teng
A 3-Dimensional In Silico Test Bed For Radiofrequency Ablation Catheter Design Evaluation And Optimization, Carolyn Teng
Master's Theses
Atrial fibrillation (AF) is the disordered activation of the atrial myocardium, which is a major cause of stroke. Currently, the most effective, minimally traumatic treatment for AF is percutaneous catheter ablation to isolate arrhythmogenic areas from the rest of the atrium. The standard in vitro evaluation of ablation catheters through lesion studies is a resource intensive effort due to tissue variability and visual measurement methods, necessitating large sample sizes and multiple prototype builds. A computational test bed for ablation catheter evaluation was built in SolidWorks® using the morphology and dimensions of the left atrium adjacent structures. From this geometry, the …
On-Demand Label Production, Robert A. Zimmerman
On-Demand Label Production, Robert A. Zimmerman
Master's Theses
The production and approval process for the various labels used in clinical trials wastes significant time and resources through the need to outsource label production or rely on large reams of pre-cut label stock for each revision throughout the process. An in-house, on-demand label printing and cutting system is a potential remedy to this waste. Previous work by Cheadle et al. resulted in a functional electomechanical prototype of the label cutting aspect of this research, capable of rudimentary linear cuts. In this continued research, emphasis was placed on improved label cutting capabilities and creating PC control software for label design. …
Development Of A Myoelectric Detection Circuit Platform For Computer Interface Applications, Nickolas Andrew Butler
Development Of A Myoelectric Detection Circuit Platform For Computer Interface Applications, Nickolas Andrew Butler
Master's Theses
Personal computers and portable electronics continue to rapidly advance and integrate into our lives as tools that facilitate efficient communication and interaction with the outside world. Now with a multitude of different devices available, personal computers are accessible to a wider audience than ever before. To continue to expand and reach new users, novel user interface technologies have been developed, such as touch input and gyroscopic motion, in which enhanced control fidelity can be achieved. For users with limited-to-no use of their hands, or for those who seek additional means to intuitively use and command a computer, novel sensory systems …
Assessing Endothelial Dysfunction Estimating The Differences Between 3 Minute And 5 Minute Reactive Hyperemia, Tamiko K. Saldin
Assessing Endothelial Dysfunction Estimating The Differences Between 3 Minute And 5 Minute Reactive Hyperemia, Tamiko K. Saldin
Master's Theses
The purpose of this study was to define a lower standard cuff occlusion time to induce reactive hyperemia in assessing endothelial dysfunction. In this study, strong evidence was found by a novel technique that used oscillometric methods, which supported that 3 minute reactive hyperemia was sufficient to elicit a significant difference in arterial compliance from baseline. Twenty healthy Cal Poly students were assessed, (n=12 female, n=8 male) aged 22 years old with a standard deviation of 2.04 years. Arterial compliance was estimated by measuring the peak-to-peak oscillations for baseline, 3 minute reactive hyperemia, and 5 minute reactive hyperemia tests, with …