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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 4 of 4
Full-Text Articles in Biomedical Engineering and Bioengineering
Continuous, Non-Destructive Detection Of Surface Bacterial Growth With Bioinspired Vascularized Polymers, Brandon Dixon
Continuous, Non-Destructive Detection Of Surface Bacterial Growth With Bioinspired Vascularized Polymers, Brandon Dixon
Electronic Theses and Dissertations
Reducing or eliminating bacteria on surfaces is vital for medical devices, drinking water quality, and industrial processes. Evaluating surface bacterial growth at buried interfaces can be problematic due to the time-consuming disassembly process required for obtaining standard surface samples. In this work, a continuous, non-destructive, and reusable method was developed to detect surface bacterial growth at buried interfaces. Inspired by vascular systems in nature that permit chemical communication between the surface and underlying tissues of an organism, bacterial-specific signals diffusing from cells on the surface were detected in channels filled with an inert carrier fluid embedded in a polymer matrix. …
A Microfluidic Assay For Single Cell Bacterial Adhesion Studies Under Shear Stress, Amanda Trusiak
A Microfluidic Assay For Single Cell Bacterial Adhesion Studies Under Shear Stress, Amanda Trusiak
Electronic Theses and Dissertations
The study of bacterial adhesion to host cells is important in understanding bacterial pathogenesis and developing new therapeutic approaches. Here, we studied bacterial adhesion under shear stress using a novel microfluidic method. Specifically, the adhesion of a uropathogenic E. coli strain (FimHOn, ATCC 700928/CFT073) to mannose-modified substrates was studied under flow conditions. The FimHOn E. coli strain expresses FimH which is a mannose-specific adhesin found on the fimbriae that binds to glycoproteins on the epithelium. We developed a microfluidic method that mimics bacterial adhesion to urothelial cells. First, the microfluidic channels were modified by sequentially adsorbing BSA-mannose and BSA onto …
Contact Simulation For Evaluating Patient Specific Surgical Guide Stability, Vincent Nierste
Contact Simulation For Evaluating Patient Specific Surgical Guide Stability, Vincent Nierste
Electronic Theses and Dissertations
This study proposes a novel computational method to quantify guide stability for Patient Specific Instrumentation (PSI) guides. A finite element contact model was used to analyze the final position of PSI guides on a femur across a range of loading parameters representing forces applied by a surgeon during operative use. Separate segmentation methods were used for the guide and bone geometry to represent differences between segmentation and actual patient geometry. The region of loading parameters over which the guide exhibited a consistent final position was measured and reported as Guide Stability Score. The model was verified using cadaver specimens for …
Controlled Voltage Of Hot Snare Polypectomy Device In Electrosurgical Device, Saidi Olayinka Olalere
Controlled Voltage Of Hot Snare Polypectomy Device In Electrosurgical Device, Saidi Olayinka Olalere
Electronic Theses and Dissertations
The study is used to understand the working procedure of the Olympus PSD-30 Electrosurgical Unit which a high-frequency alternating current is to measure the voltage and power output from the unit when used for a surgical operation to determine the extent of tissue damage. The output power and voltage were as examined with the stopwatch, then with an Arduino time based for 1, 2, and 3 seconds to understand the different modes of the cut and coagulation feedback with an RCC circuit used to mimic the human body. This shows a pattern in which the feedback power increases, and voltage …