Biomedical Engineering and Bioengineering Commons^™

Repair And Regeneration Of Chondral Defects: An In Vitro Study Demonstrating Feasibility And Mechanism Under Low Intensity Ultrasound, Neety Sahu, Anuradha Subramanian

Department of Chemical and Biomolecular Engineering: Theses and Student Research

Holistic repair of damaged cartilage remains an unsolved biomedical problem. Current methods that employ microfracture (MF) or autologous chondrocyte implantation (ACT) or tissue engineered strategies yield inferior repaired cartilage (Fig. 1). Lack of chondroinductive factors at the site of injury, in vivo, has been identified as a factor that limits repair. Clinically amenable strategies that can improve repair are desired. A novel clinically translatable repair strategy based on low-intensity-ultrasound (US) is proposed (Fig.2). Differently from all approaches that use US, our approach employs US at the cell resonant frequency where bioeffects are maximized. We have shown that US impacts the …