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Biomedical Engineering and Bioengineering Commons™
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- Keyword
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- Additive Manufacturing (2)
- Ataxia (1)
- Backbone exoskeleton (1)
- Biomarker Detection (1)
- Biomechanics Simulation; OpenSim; Flexion/Extension; Exoskeleton; "Push-pull" (1)
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- Biosensor development (1)
- CMOS Active Pixel Sensor (1)
- CMOS imager (1)
- Compliant (1)
- Decision tree (1)
- Design (1)
- EEG (1)
- EOG (1)
- Electrochemical sensor (1)
- Engineering Design (1)
- Ergometer (1)
- Exoskeleton (1)
- Eyewear (1)
- Facial Expressions (1)
- Fatigue (1)
- Fluorescence imaging (1)
- Fluorescence lifetime (1)
- Haptics (1)
- Hip (1)
- Hydrogel (1)
- Hydrophobic tagging (1)
- IMU (1)
- Intent recognition (1)
- Isokinetic (1)
- Isotonic (1)
- Publication Year
- Publication Type
Articles 1 - 13 of 13
Full-Text Articles in Biomedical Engineering and Bioengineering
Reactive Chemistries For Protein Labeling, Degradation, And Stimuli Responsive Delivery, Myrat Kurbanov
Reactive Chemistries For Protein Labeling, Degradation, And Stimuli Responsive Delivery, Myrat Kurbanov
Doctoral Dissertations
Reactive chemistries for protein chemical modification play an instrumental role in chemical biology, proteomics, and therapeutics. Depending on the application, the selectivity of these modifications can range from precise modification of an amino acid sequence by genetic manipulation of protein expression machinery to a stochastic modification of lysine residues on the protein surface. Ligand-Directed (LD) chemistry is one of the few methods for targeted modification of endogenous proteins without genetic engineering. However, current LD strategies are limited by stringent amino acid selectivity. To bridge this gap, this thesis focuses on the development of highly reactive LD Triggerable Michael Acceptors (LD-TMAcs) …
Enabling Daily Tracking Of Individual’S Cognitive State With Eyewear, Soha Rostaminia
Enabling Daily Tracking Of Individual’S Cognitive State With Eyewear, Soha Rostaminia
Doctoral Dissertations
Research studies show that sleep deprivation causes severe fatigue, impairs attention and decision making, and affects our emotional interpretation of events, which makes it a big threat to public safety, and mental and physical well-being. Hence, it would be most desired if we could continuously measure one’s drowsiness and fatigue level, their emotion while making decisions, and assess their sleep quality in order to provide personalized feedback or actionable behavioral suggestions to modulate sleep pattern and alertness levels with the aim of enhancing performance, well-being, and quality of life. While there have been decades of studies on wearable devices, we …
Unobtrusive Assessment Of Upper-Limb Motor Impairment Using Wearable Inertial Sensors, Brandon R. Oubre
Unobtrusive Assessment Of Upper-Limb Motor Impairment Using Wearable Inertial Sensors, Brandon R. Oubre
Doctoral Dissertations
Many neurological diseases cause motor impairments that limit autonomy and reduce health-related quality of life. Upper-limb motor impairments, in particular, significantly hamper the performance of essential activities of daily living, such as eating, bathing, and changing clothing. Assessment of impairment is necessary for tracking disease progression, measuring the efficacy of interventions, and informing clinical decision making. Impairment is currently assessed by trained clinicians using semi-quantitative rating scales that are limited by their reliance on subjective, visual assessments. Furthermore, existing scales are often burdensome to administer and do not capture patients' motor performance in home and community settings, resulting in a …
Surface Enhanced Raman Spectroscopy (Sers) As An Approach For The Emerging Liquid Biopsy Diagnostics, Nariman Banaei
Surface Enhanced Raman Spectroscopy (Sers) As An Approach For The Emerging Liquid Biopsy Diagnostics, Nariman Banaei
Doctoral Dissertations
Large Molecule bioanalysis and biosensor development are essential techniques that are required in many applications, including biotherapeutic development, in vitro diagnostic, biomarker detection, and early detection. These techniques should be highly specific and sensitive enough to identify and quantify an analyte of interest with minimum sample pretreatment requirements. This work explores the development and application of chip-scale bioassays based on surface-enhanced Raman scattering (SERS). It introduces sensing techniques to quantify various disease biomarkers, specifically pancreatic cancer. Blood is the best source of information about our body's function. There are many biomarkers in the blood, and each biomarker's high expression level …
Direct Printing/Patterning Of Key Components For Biosensor Devices, Yiliang Zhou
Direct Printing/Patterning Of Key Components For Biosensor Devices, Yiliang Zhou
Doctoral Dissertations
Recently, biosensor devices, especially wearable devices for monitoring human health, have attracted significant interests and meanwhile, they have a huge market. These wearable biosensor devices usually consist of several key components, including microfluidics, biosensing elements and power supply. Though advanced sensing platforms have been extensively explored, high manufacturing fee and lack of practical functions are the main reasons that most of devices and techniques are still out of reach for potential users. This dissertation focuses on fabricating these key components for biosensor devices via advanced printing/patterning techniques, such as inkjet-printing and nanoimprinting. These fabrication techniques can be potentially extended to …
Supporting Engineering Design Of Additively Manufactured Medical Devices With Knowledge Management Through Ontologies, Thomas Hagedorn
Supporting Engineering Design Of Additively Manufactured Medical Devices With Knowledge Management Through Ontologies, Thomas Hagedorn
Doctoral Dissertations
Medical environments pose a substantial challenge for engineering designers. They combine significant knowledge demands with large investment for new product development and severe consequences in the case of design failure. Engineering designers must contend with an often-chaotic environment to which they have limited access and familiarity, a user base that is difficult to engage and highly diverse in many attributes, and a market structure that often pits stakeholders against one another. As medical care in general moves towards personalized models and surgical tools towards less invasive options emerging manufacturing technologies in additive manufacturing offer significant potential for the design of …
A Magnetic Resonance Compatible Knee Extension Ergometer, Youssef Jaber
A Magnetic Resonance Compatible Knee Extension Ergometer, Youssef Jaber
Masters Theses
The product of this thesis aims to enable the study of the biochemical and physical dynamics of the lower limbs at high levels of muscle tension and fast contraction speeds. This is accomplished in part by a magnetic resonance (MR) compatible ergometer designed to apply a load as a torque of up to 420 Nm acting against knee extension at speeds as high as 4.7 rad/s. The system can also be adapted to apply the load as a force of up to 1200 N acting against full leg extension. The ergometer is designed to enable the use of magnetic resonance …
Development Of A Portable Cmos Time-Domain Fluorescence Lifetime Imager, Hongtao Wang
Development Of A Portable Cmos Time-Domain Fluorescence Lifetime Imager, Hongtao Wang
Doctoral Dissertations
Modern laboratory equipments to measure the excited-state lifetime of fluorophores usually include an expensive picosecond pulsed-laser excitation source, a fragile photomultiplier tube, and a large instrument body for optics. A portable and robust device to make fluorescence lifetime measurement in nanosecond scale is of great attraction for chemists and biologists. This dissertation reports the development of a portable LED time-domain fluorimeter from an all-solid-state discrete-component prototype to its advanced CMOS integrated circuit implementation. The motivation of the research is to develop a multiplexed fluorimeter for point-of-care diagnosis. Instruments developed by this novel method have higher fill factor, are more portable, …
A Haptic Surface Robot Interface For Large-Format Touchscreen Displays, Mark Price
A Haptic Surface Robot Interface For Large-Format Touchscreen Displays, Mark Price
Masters Theses
This thesis presents the design for a novel haptic interface for large-format touchscreens. Techniques such as electrovibration, ultrasonic vibration, and external braked devices have been developed by other researchers to deliver haptic feedback to touchscreen users. However, these methods do not address the need for spatial constraints that only restrict user motion in the direction of the constraint. This technology gap contributes to the lack of haptic technology available for touchscreen-based upper-limb rehabilitation, despite the prevalent use of haptics in other forms of robotic rehabilitation. The goal of this thesis is to display kinesthetic haptic constraints to the touchscreen user …
Point Of Care Diagnostics And Health Monitoring Devices, Akshaya Shanmugam
Point Of Care Diagnostics And Health Monitoring Devices, Akshaya Shanmugam
Doctoral Dissertations
Existing disease screening methods mostly rely on symptom based diagnosis. This is mainly because of lack of accessibility and cost associated with the tests. Testing for the presence of the disease after the onset of symptoms has a negative impact on chances of survival and treatment costs. Miniaturized low cost diagnostic devices that can be used outside the hospital setting can provide continuous health monitoring and aid in early diagnosis. This thesis presents techniques to develop such disease screening and health monitoring devices. The techniques presented here focus on medical devices that can benefit from microfluidic devices, fluorescence imaging, and …
A Continous Rotary Actuation Mechanism For A Powered Hip Exoskeleton, Matthew C. Ryder
A Continous Rotary Actuation Mechanism For A Powered Hip Exoskeleton, Matthew C. Ryder
Masters Theses
This thesis presents a new mechanical design for an exoskeleton actuator to power the sagittal plane motion in the human hip. The device uses a DC motor to drive a Scotch yoke mechanism and series elasticity to take advantage of the cyclic nature of human gait and to reduce the maximum power and control requirements of the exoskeleton. The Scotch yoke actuator creates a position-dependent transmission that varies between 4:1 and infinity, with the peak transmission ratio aligned to the peak torque periods of the human gait cycle. Simulation results show that both the peak and average motor torque can …
Design Of A Passive Exoskeleton Spine, Haohan Zhang
Design Of A Passive Exoskeleton Spine, Haohan Zhang
Masters Theses
In this thesis, a passive exoskeleton spine was designed and evaluated by a series of biomechanics simulations. The design objectives were to reduce the human operator’s back muscle efforts and the intervertebral reaction torques during a full range sagittal plane spine flexion/extension. The biomechanics simulations were performed using the OpenSim modeling environment. To manipulate the simulations, a full body musculoskeletal model was created based on the OpenSim gait2354 and “lumbar spine” models. To support flexion and extension of the torso a “push-pull” strategy was proposed by applying external pushing and pulling forces on different locations on the torso. The external …
Activity Intent Recognition Of The Torso Based On Surface Electromyography And Inertial Measurement Units, Zhe Zhang
Masters Theses 1911 - February 2014
This thesis presents an activity mode intent recognition approach for safe, robust and reliable control of powered backbone exoskeleton. The thesis presents the background and a concept for a powered backbone exoskeleton that would work in parallel with a user. The necessary prerequisites for the thesis are presented, including the collection and processing of surface electromyography signals and inertial sensor data to recognize the user’s activity. The development of activity mode intent recognizer was described based on decision tree classification in order to leverage its computational efficiency. The intent recognizer is a high-level supervisory controller that belongs to a three-level …