Biomedical Engineering and Bioengineering Commons^™

Direct Analysis Of Pharmaceutical Drugs In Biofluids Using Miniature Mass Spectrometry System, Spencer Chiang, Yue Ren, Zheng Ouyang

The Summer Undergraduate Research Fellowship (SURF) Symposium

Miniature mass spectrometry (MS) system is key for establishing MS as a point-of-care chemical and biological analysis within clinical settings. In order to provide point-of-care diagnostics, ionization methods for direct analysis of biofluids are required. We have previously introduced paper spray and developed the cartridges for direct MS ionization and sampling. Our goal of this research is to identify a viable way to improve the spray efficacy of paper spray for its coupling with miniature MS. As a result, paper capillary spray (PCS) was developed. PCS utilizes ET31 paper with a fused-silica capillary fixated to the tip. The design was …