Biomedical Engineering and Bioengineering Commons^™

Computational Methodology For Generating Patient-Specific Soft Tissue Representations, Ahilan Anantha Krishnan

Electronic Theses and Dissertations

This dissertation focused on modeling specimen-specific soft tissue structures in the context of joint replacement surgery. The research addressed four key aspects. The first study involved developing a workflow for creating finite element models of the hip capsule to replicate its torque-rotational response. Experimental data from ten cadaveric hips were used to calibrate the models, resulting in improved accuracy and relevance for surgical planning and implant design. The second study tackled the challenge of expediting the calibration of mechanical properties of the hip capsule to match patient-specific laxities. A statistical shape function model was proposed to generate patient-specific finite element …

Digital Twins Of The Living Knee: From Measurements To Model, Thor Erik Andreassen

Electronic Theses and Dissertations

Modern medicine has dramatically improved the lives of many. In orthopaedics, robotic surgery has given clinicians superior accuracy when performing interventions over conventional methods. Nevertheless, while these and many other methods are available to ensure treatments are performed successfully, far fewer methods exist to predict the proper treatment option for a given person. Clinicians are forced to categorize individuals, choosing the best treatment on “average.” However, many individuals differ significantly from the “average” person, for which many of these treatments are designed. Going forward, a method of testing, evaluating, and predicting different treatment options' short- and long-term effects on an …

Patient Movement Monitoring Based On Imu And Deep Learning, Mohsen Sharifi Renani

Electronic Theses and Dissertations

Osteoarthritis (OA) is the leading cause of disability among the aging population in the United States and is frequently treated by replacing deteriorated joints with metal and plastic components. Developing better quantitative measures of movement quality to track patients longitudinally in their own homes would enable personalized treatment plans and hasten the advancement of promising new interventions. Wearable sensors and machine learning used to quantify patient movement could revolutionize the diagnosis and treatment of movement disorders. The purpose of this dissertation was to overcome technical challenges associated with the use of wearable sensors, specifically Inertial Measurement Units (IMUs), as a …

Mitral Valve Imaging And Biomechanics: A Workflow Towards Computational Modeling And Validation, Sam Stephens

Graduate Theses and Dissertations

The mitral valve serves a critical role in healthy cardiac function by ensuring the unidirectional flow of oxygenated blood from the left atrium into the left ventricle. It experiences the highest pressures found within the heart and its closure is the result of a complex interaction of several different structures that, furthermore, are unique to each individual. Despite the valve’s vital role however, the specific function of these constituent structures is not fully understood. This, confounded by its asymmetric, personalized nature, make surgical interventions for the mitral valve far less effective than for its neighboring aortic valve. Efforts to overcome …

Effect Of Amputation On Muscle Structure Properties In A Rabbit Model, Roy Caleb Stubbs

Masters Theses

After amputation, muscles in the residual limb are detached from their insertion points and no longer span the missing joints. Our objective was to quantify the effect of amputation-induced disuse on residual muscle structure, an indirect indicator of muscle force-generating capacity. One hind paw was surgically removed at the ankle joint of ten rabbits. At two weeks (n=5) and 4 weeks (n=5) post-amputation and for select muscles (gastrocnemius, soleus, tibialis cranialis, extensor digitorum, and flexor digitorum superficialis), we measured and computed several muscle structure properties. Additionally, we qualitatively assessed the muscle fiber appearance of histological samples at each timepoint. At …

Making Sense Of Big (Kinematic) Data: A Comprehensive Analysis Of Movement Parameters In A Diverse Population, Naomi Wilma Nunis

University of the Pacific Theses and Dissertations

OBJECTIVE

The purpose of this study was to determine how kinematic, big data can be evaluated using computational, comprehensive analysis of movement parameters in a diverse population.

METHODS

Retrospective data was collected, cleaned, and reviewed for further analysis of biomechanical movement in an active population using 3D collinear resistance loads. The active sample of the population involved in the study ranged from age 7 to 82 years old and respectively identified as active in 13 different sports. Moreover, a series of exercises were conducted by each participant across multiple sessions. Exercises were measured and recorded based on 6 distinct biometric …

Recent Advances In Bone Research 2022 Edition, Jean-Philippe Berteau, Laurent Pujo-Menjouet

Publications and Research

More and more scientific and engineering applications in bone research make pivotal advances in treating patients with orthopedics issues. Hence, bone research in the 21st century combines, inter alia, biology, chemistry, mathematics, and mechanics with complementary characteristics that help a holistic approach to bone-related pathologies. Nowadays, it is hard to connect new evidence when jargoning and money remain two significant obstacles to sharing knowledge. “Recent Advances In Bone Research” is a free book – no money involved at any stage - that combines the most recent efforts in bone research from several experts with different backgrounds, every expert seeks to …

A Novel Ultrasound Elastography Technique For Evaluating Tumor Response To Neoadjuvant Chemotherapy In Patients With Locally Advanced Breast Cancer, Niusha Kheirkhah

Electronic Thesis and Dissertation Repository

Breast cancer is the second most diagnosed cancer in women, estimated to affect 1 in 8 women during their lifetime. About 10% to 20% of new breast cancer cases are diagnosed with locally advanced breast cancer (LABC). LABC tumors are usually larger than 5 cm and/or attached to the skin or chest wall. It has been reported that when such cases are treated with surgery alone, metastasis and mortality rates are high, especially where skin involvement or attachment to the chest wall is extensive. As such, efficient treatment for this kind of breast cancer includes neoadjuvant chemotherapy (NAC) to shrink …

Biomechanical Analysis Of Athletes Sprinting With Varying Degrees Of Resistance, Michaela Ott

Honors Theses

Utilizing resistance methods for sprinters is a common approach to their training. In this study, six athletes from the University of Nebraska-Lincoln Women’s Track and Field Team ran a series of sprints using a resistance machine to collect data regarding the change in power output, stride length, level of trunk tilt with respect to the ground, and acceleration throughout a distance of ten meters when different amounts of resistant forces were applied to the athlete. It was hypothesized that as resistance increased, power output would increase, stride length would decrease, the runners would become more horizontal resulting in a larger …

Youth Pitching Kinematics: Associations With Body Overweight Parameters, Christina K. Fong

Master's Theses

The objective of this study was to investigate associations between injury-related kinematic parameters and overweight measures for youth baseball pitchers. The injury-related kinematic parameters considered were measurements 1) at foot contact: stride length, front foot position, shoulder external rotation, shoulder abduction, and elbow flexion; 2) between FC and ball release: peak knee extension; and 3) at BR: shoulder abduction. Data from three separate collection sites examined pitching mechanics of 18 10- to 11-year-old pitchers, 11 14- to 16-year-old pitchers, and 104 16- to 18-year-old pitchers Linear regression analyses were performed to determine significant correlations between kinematic parameters and body mass …

Characterizing Locomotor Disturbance Perception In Young Adults, Daniel James Liss

Graduate Theses, Dissertations, and Problem Reports

Falls during walking are a leading cause of injuries across aging. Many of these falls are due to slips and trips. The ability to perceive disturbances to ongoing motion may play an important role in the control of walking balance. However, disturbance perception has been investigated in standing balance, but its role in walking balance due to slip- and trip-like disturbances remains largely unknown. Characterizing locomotor disturbance perception in young adults may lead to a more comprehensive understanding of sensorimotor walking balance control.

This work defined locomotor disturbance perception in response to slip and trip-like disturbances in young adults. We …

Effect Of Viscoelasticity On Cellular Morphology And Activity, Thomas J. Petet Jr

Theses and Dissertations

It has been well established that there is a link between substrate stiffness and cellular activities such as proliferation, migration, and differentiation. Less characterized is the link between the time-dependent viscosity of a substrate with those cellular activities. To explore this, PDMS substrates were created with predictably tunable stiffness and viscosity parameters. A simulated model was also developed in parallel to explore the potential effects of viscosity in a computationally predictive way. It was found that the inclusion of viscosity caused a major paradigm shift to a non-zero substrate equilibrium that was sensitive to increases in the substrate stiffness. Finally, …

An Investigation Into The Plate Fixation For Periprosthetic Femoral Fractures, Xiang Chen

Electronic Theses and Dissertations

Periprosthetic femoral fractures are the third most reason for reoperation after the total hip arthroplasty with an incident rate of approximately 6%. The Vancouver type B periprosthetic femoral fractures account for over 70% of all cases, while the sub-type B1 fracture (when the total hip stem is stable) has remained a clinical challenge due to incidences of severe complications after the standard plate-screw fixation. To seek biomechanically sound fixations for the Vancouver type B1 fracture, this dissertation developed a combined modeling and testing framework to investigate the efficacy of fixation for a Vancouver type B1 fracture using different construct lengths …

Multi-Task Neuromuscular Generalization And Changes Through The Lifespan, Hannah Delaney Carey

Graduate Theses, Dissertations, and Problem Reports

Mobility in everyday life requires executing and shifting between a broad assortment of functional tasks and resisting disturbances that could cause falls. Though the importance of successfully performing a variety of functional tasks is recognized and incorporated in clinical assessments (e.g., the Timed-Up-and-Go Test, Berg Balance Scale), little is understood about the underlying neuromuscular control required, or how it changes with age. The neuromuscular control for functional tasks such as walking is typically studied in isolation, or with variations on the same task. Characterizing the coordination required to produce and shift between a wider variety of tasks and resist external …

Collision Tracking And Brain Mapping, Carl Russell Iii

The Journal of Purdue Undergraduate Research

No abstract provided.

Drive Leg And Stride Leg Ground Reaction Forces Relationship To Medial Elbow Stress And Velocity In Collegiate Baseball Pitchers, Brett Smith

Biomedical Engineering Theses & Dissertations

This study examines several different kinetic variables in relation to pitch velocity and elbow varus torque in collegiate baseball pitchers using force plates, an inertial measurement unit, and a radar unit. The purpose of this study is to investigate the kinetic variables being measured and their relationship to pitch velocity and loads being placed on the medial elbow. Twelve collegiate baseball pitchers participated in this study, which was approved by the IRB. Impulse of the drive leg in the anterior-posterior direction, stride leg peak force in the anterior-posterior (AP) direction, elbow varus torque, and pitch velocity were all measured. Two …

In Vitro Analyses Of The Contributions Of The Hip Capsule To Joint Biomechanics, Emma Donnelly

Electronic Thesis and Dissertation Repository

Optimal management of the hip capsule during arthroscopic surgery has not been established. The impact of incisions made to the capsule during minimally invasive procedures on joint biomechanics, and whether repair provides any benefit, continue to be debated. The effectiveness of capsular repair to restore native kinematics may be insufficient. Therefore, a better understanding of joint behavior during various capsule conditions is needed. A new robotic system was used to analyze the effect of progressive capsulotomy incision and repairs on the behavior of a normal hip within range of motion (ROM) limits with respect to the intact joint. Complete repairs …

Dislocation Mechanics Of Total Hip Arthroplasty: A Combined Experimental And Computational Analysis, Michael Scinto

Electronic Theses and Dissertations

While total hip arthroplasty is considered a successful procedure, dislocation remains a serious complication as recurrent dislocations may require additional surgeries. Knowledge on dislocation events as they occur in vivo are limited, therefore researchers rely on experimental and computational methods. A custom MATLAB script and an experimental procedure utilizing a six-degree of freedom actuator were developed to further understand how various surgical considerations affect dislocation mechanics in total hip arthroplasty. Computationally, it was determined that impingement free range of motion is limited during internal rotation in flexion and during external rotation in extension. Experimentally, our results suggest that the posterior …

Feasibility Study To Measure The Impact Of A Specialized Core Exercise On Metabolic Efficiency And Stability During Walking For Above Knee Amputees, Shaye M. Tiell, Sabrina R. Segretario, Serena M. Myers, Emily G. Tully

Williams Honors College, Honors Research Projects

The objective of this study is to determine the feasibility of improving the gait of above-knee (AK) amputees by performing daily core exercises aimed to provide an efficient and stable walking pattern. The goal of the exercise is to strengthen core muscles and form temporary neural connections in the brain aimed at improving metabolic efficiency and stability. We will be implementing the Wright Balance Core 360 Exercise Technique for completion by our subjects. Motion capture technology will be utilized in conjunction with a metabolic oxygen consumption analyzer to collect stability and metabolic efficiency data while amputees walk on a treadmill. …

Smartphone-Tape Method For Calculating Body Segment Inertial Parameters For Analysis Of Pitching Arm Kinetics, Jay Sterner

Master's Theses

The objectives of this study were to (1) develop a non-invasive method (referred to as Smart Photo-Tape) to calculate participant-specific upper arm, forearm, and hand segment inertial properties (SIPs) (e.g. mass, center of mass, and radii of gyration) and (2) use those Smart Photo-Tape properties in inverse dynamics (ID) analyses to calculate injury-related pitching arm kinetics. Five 20- to 23- year-old baseball pitchers were photographed holding a baseball and analyzed using the Smart Photo-Tape method to obtain 3-D inertial properties for their upper arm, forearm, and hand. The upper arm and forearm segments were modelled as stacked elliptic cylinders and …

Atv Dynamics And Pediatric Rider Safety, James T. Auxier Ii

Theses and Dissertations--Biomedical Engineering

It has been observed through numerous academic and governmental agency studies that pediatric all-terrain vehicle ridership carries significant risk of injury and death. While no doubt valuable to safety, the post-hoc approach employed in these studies does little to explain the why and how behind the risk factors. Furthermore, there has been no prolonged, widespread, organized, and concerted effort to reconstruct and catalog the details and causes of the large (20,000+) number of ATV-related injuries that occur each year as has been done for road-based motor vehicle accidents. This dissertation takes the opposite approach from a meta-analysis and instead examines …

The Effect Of Implant Conformity On Muscle Force Requirements In The Implanted Knee, Grace Mcconnochie

Boise State University Theses and Dissertations

Implant geometry is a significant factor in determining knee stability and patient satisfaction following total knee replacement (TKR). Ineffective muscle recruitment, impaired joint functionality and increased implant wear are consequences of an unstable knee replacement. Current knee laxity evaluation techniques are limited in their ability to account for the muscular response to knee instability. This study utilizes a subject specific lower-body musculoskeletal finite element (FE) model with dynamic muscle loading to evaluate implant laxity during activities of daily living. The effect of varying implant conformity on the muscle forces required to maintain a target kinematic profile during simulated laxity testing …

Role Of Angiotensin I And Ii On The Tissue Mechanics Of The Aortic Heart Valve Via Receptor Binding And Converting Enzymes, Josh Fahy

Biomedical Engineering Undergraduate Honors Theses

The renin-angiotensin system (RAS) plays a crucial role in the regulation of renal, cardiac, and vascular physiology. This system regulates in vivo blood pressure and fluid balance. As renal blood flow decreases, the kidneys convert prorenin into renin and secrete it into the circulatory system. Renin then converts angiotensinogen into angiotensin I (ang-I). The ang-I is then converted into angiotensin II (ang-II) by the angiotensin-converting enzyme (ACE). Ang-II, a vasoconstrictor, increases blood pressure by causing the blood vessels to narrow. Recent evidence suggests that RAS may be involved in the progression of valve disease, most notably, aortic stenosis.

The first …

Kinematics During Knee Extension, Lunge, And Chair Rise, Center For Orthopaedic Biomechanics, Kevin Shelburne, Phd, Michael D. Harris, Phd, Vasiliki Kefala, Donald R. Hume, Bradley S. Davidson, A. J. Cyr, R. H. Kim, A. A. Ali, E. M. Mannen

Living Kinematics of the Knee

No abstract provided.

Thenar Muscle And Transverse Carpal Ligament Relationship, Jeremy Granieri Loss

ETD Archive

The transverse carpal ligament (TCL) acts as a partial origin for the thenar muscles (abductor pollicis brevis (APB), flexor pollicis brevis (FPB), opponens pollicis (OPP)). The attachment between the thenar muscles and TCL implies a relationship between the tissues. The thenar muscles rely on their origins for thumb motion and force production. However, individual thenar origin information is lacking. Further information regarding the anatomical relationship between the individual thenar muscles and TCL may provide insight into thenar muscle function. In addition, the TCL responds to thenar muscle contraction as shown by volar migration of the TCL during various thumb movements. …

Development And Exploration Of A Z-Shaped Foot And Ankle Internal Fixation Plate, Rhaz Shaghaghi Paul, Ian Hames, Sean Rich

Williams Honors College, Honors Research Projects

This paper will detail the design process of developing a Z-shaped foot and ankle internal fixation plating system. Group 6: Plates for the Sole was made up of 5 team members, who worked together to accommodate their client’s request to complete a biomechanical analysis of a Z-Plate design and a construct a prototype. The Z-Plate’s purpose is to provide podiatrists with a new solution that can fit nicely on the small, irregular bones of the foot, while also remaining strong enough to withstand the forces and torques of the foot.

Connecting The Pieces: How Low Back Pain Alters Lower Extremity Biomechanics And Shock Attenuation In Active Individuals, Alexa Johnson

Theses and Dissertations--Rehabilitation Sciences

Low back pain in collegiate athletes has been reported at a rate of 37% from a wide array of sports including soccer, volleyball, football, swimming, and baseball. Whereas, in a military population the prevalence of low back pain is 70% higher than the general population. Compensatory movement strategies are often used as an attempt to reduce pain. Though compensatory movement strategies may effectively reduce pain, they are often associated with altered lower extremity loading patterns. Those who suffer from chronic low back pain tend to walk and run slower and with less trunk and pelvis coordination and variability. Individuals with …

Acromial Insufficiency Fractures In Reverse Total Shoulder Arthroplasty: A Biomechanical Study, Alicia Kerrigan

Electronic Thesis and Dissertation Repository

Reverse total shoulder arthroplasty (RTSA) is increasingly utilized in the aging population, with a growing list of surgical indications including rotator cuff tear arthropathy, proximal humerus fractures, and revision arthroplasty. Acromial insufficiency fractures following RTSA are poorly understood, difficult to diagnose, and associated with inferior clinical outcomes. There is limited knowledge in the literature regarding the etiology of post-operative acromial fractures. The purpose of this study is to evaluate the role of implant parameters on acromial strain following RTSA.

Using a cadaveric model, a custom designed modular RTSA system was implanted that allowed for evaluation of modifiable parameters including glenoid …

Hip And Knee Biomechanics For Transtibial Amputees In Gait, Cycling, And Elliptical Training, Greg Orekhov

Master's Theses

Transtibial amputees are at increased risk of contralateral hip and knee joint osteoarthritis, likely due to abnormal biomechanics. Biomechanical challenges exist for transtibial amputees in gait and cycling; particularly, asymmetry in ground/pedal reaction forces and joint kinetics is well documented and state-of-the-art passive and powered prostheses do not fully restore natural biomechanics. Elliptical training has not been studied as a potential exercise for rehabilitation, nor have any studies been published that compare joint kinematics and kinetics and ground/pedal reaction forces for the same group of transtibial amputees in gait, cycling, and elliptical training. The hypothesis was that hip and knee …

Inverse Dynamic Analysis Of Acl Reconstructed Knee Joint Biomechanics During Gait And Cycling Using Opensim, Megan V. Pottinger

Master's Theses

ACL (anterior cruciate ligament) injuries of the knee joint alter biomechanics and may cause abnormal loading conditions that place patients at a higher risk of developing osteoarthritis (OA). There are multiple types of ACL reconstruction (ACLR), but all types aim to restore anterior tibial translation and internal tibial rotation following surgery. Analyzing knee joint contact loads provide insight into the loading conditions following ACLR that may contribute to the long-term development of OA. Ten ACLR subjects, who underwent the same reconstruction, performed gait and cycling experiments while kinematic and kinetic data were collected. Inverse dynamic analyses were performed on processed …