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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Novel Methodology For Emboli Analog Production And In-Vitro Simulation Of Acute Ischemic Stroke, Anne Preut
Novel Methodology For Emboli Analog Production And In-Vitro Simulation Of Acute Ischemic Stroke, Anne Preut
Graduate Theses and Dissertations
Stroke is the leading cause of disability and a primary cause of mortality, resulting in an estimated $33 billion dollars spent on healthcare, rehabilitation and lost productivity in the United States each year. The most prevalent cause of stroke incidents are acute ischemic events, manifested as blood clots in the vasculature supplying the brain. Current gold standard treatments have improved since 2006 with the introduction of mechanical stent retrievers; however, several issues with the current treatments to acute ischemic stroke remain. Thrombolysis of the clot with a tissue plasminogen activator may lead to weakening the vessel wall and consequently, hemorrhaging. …
Effects Of Hydration And Mineralization On The Mechanical Behavior Of Collagen Fibrils, Marco Fielder
Effects Of Hydration And Mineralization On The Mechanical Behavior Of Collagen Fibrils, Marco Fielder
Graduate Theses and Dissertations
Bone is a composite biomaterial with a structural load-bearing function. Understanding the biomechanics of bone is important for characterizing factors such as age, trauma, or disease, and in the development of scaffolds for tissue engineering and bioinspired materials. At the nanoscale, bone is primarily composed of collagen protein, apatite crystals, and water. Though several studies have characterized nanoscale bone mechanics as the mineral content changes, the effect of water, mineral, and carbon nanotube (CNT) content and distribution in fibril gap and overlap regions is unexplored. This study used molecular dynamics to investigate the change in collagen fibril deformation mechanisms as …