Biomedical Engineering and Bioengineering Commons^™

Release Kinetics Of Metronidazole From 3d Printed Silicone Scaffolds., Sydney E. Herold

Electronic Theses and Dissertations

Sustained local administration of active agents has been proposed to cure bacterial vaginosis in the female reproductive tract and restore the resident bacterial fauna. Bioprinting has shown promise for the development of systems for local agent delivery. In contrast to oral ingestion, agent release kinetics can be fine-tuned by bioprinting specialized scaffold designs tailored for particular treatments while enhancing dosage effectiveness via localized sustained release. It has been challenging to establish scaffold properties for sustained release as a function of fabrication parameters. Towards this goal, we evaluate 3D printed scaffold formulation and feasibility to sustain release of metronidazole, a representative …