Biomedical Engineering and Bioengineering Commons^™

A Distributed Model Of Carbohydrate Transport And Metabolism In The Liver During Rest And High-Intensity Exercise, E Chalhoub, L. Xie, V. Balasubramanian, Joanne M. Belovich

Chemical & Biomedical Engineering Faculty Publications

A model of reaction and transport in the liver was developed that describes the metabolite concentration and reaction flux dynamics separately within the tissue and blood domains. The blood domain contains equations for convection, axial dispersion, and transport to the surrounding tissue; and the tissue domain consists of reactions representing key carbohydrate metabolic pathways. The model includes the metabolic heterogeneity of the liver by incorporating spatial variation of key enzymatic maximal activities. Simulation results of the overnight fasted, resting state agree closely with experimental values of overall glucose uptake and lactate output by the liver. The incorporation of zonation …